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Analytical Chemistry Reference from C.H.I.P.S.

Analysis and Purification Methods in Combinatorial Chemistry
edited by Bing Yan

Analysis and Purification Methods in Combinatorial Chemistry delivers the latest in this fast-moving field. It describes various analytical techniques and systems for the development, validation, quality control, purification, and physiochemical testing of combinatorial libraries.

The text contains 4 parts covering:

  • Various approaches to monitor reactions on solid support and optimize reactions for library synthesis
  • High-throughput analytical methods used to analyze the quality of the libraries
  • High-throughput purification techniques
  • Analytical methods to post-synthesis and post-purification stages

The book also contains contributions from the field's most-respected researchers and practitioners. This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

Contents

  1. Analysis for Feasibility and Optimization of Library Synthesis
    1. Quantitative Analysis in Organic Synthesis with NMR Spectroscopy
    2. 19F Gel-Phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading
    3. The Application of Single-Bead FTIR and Color Test for Reaction Monitoring and Building Block Validation in Combinatorial Library Synthesis
    4. HR-MAS NMR Analysis of Compounds Attached to Polymer Supports
    5. Multivariate Tools for Real-Time Monitoring and Optimization of Combinatorial Materials and Process Conditions
    6. Mass Spectrometry and Soluble Polymeric Support

  2. High-Throughput Analysis for Library Quality Control
    1. High-Throughput NMR Techniques for Combinatorial Chemistry Library Analysis
    2. Micellar Electrokinetic Chromatography as a Tool for Combinatorial Chemistry Analysis: Theory and Applications
    3. Characterization of Split-Pool Encoded Combinatorial Libraries

  3. High-Throughput Purification to Improve Library Quality
    1. Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries
    2. High-Throughput Purification: Triage and Optimization
    3. Parallel HPLC in High-Throughput Analysis and Purification

  4. Analysis for Compound Stability and Drugability
    1. Organic Compound Stability in Large, Diverse Phatmaceutical Screening Collection
    2. Quartz-Crystal Microbalance in Biomolecular Recognition
    3. High-Throughput Physiochemical Profiling: Potential and Limitations
    4. Solubility in the Design of Combinatorial Libraries
    5. High-Throughput Determination of Log D Values by LC/MS Method

Index

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Analysis and Purification Methods
in Combinatorial Chemistry

edited by Bing Yan
466 pages • $126.50 + shipping
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