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Carbohydrate Chemistry Reference from C.H.I.P.S.

Carbohydrate-based Drug Discovery
2 Volume Set
edited by Chi-Huey Wong

Carbohydrates play a central role in metabolism, cell-cell recognition, and pathogen defense. To exploit the full potential of this diverse compound class for the development of pharmaceutically active substances, this handbook brings together the latest in carbohydrate chemistry with recent knowledge on the biological function of carbohydrates and their derivatives.

Particular emphasis is placed on carbohydrates with pharmaceutical potential, including the most promising carbohydrate-based therapies currently available.

Carbohydrate-based Drug Discovery is a premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume set contains contributions by more than 80 leading carbohydrate chemists.

Contents

    Volume 1
  1. Synthetic Methodologies
  2. Complex Carbohydrate Synthesis
  3. The Chemistry of Sialic Acid
  4. Solid-Phase Oligosaccharide Synthesis
  5. Solution and Polymer-Supported Synthesis of Carbohydrates
  6. Enzymatic Synthesis of Oligosaccharides
  7. Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology
  8. Synthesis of Complex Carbohydrates: Everninomicin 13,384-1
  9. Chemical Synthesis of Asparagine-Linked Glycoprotein Oligosaccharides: Recent Examples
  10. Chemistry and Biochemistry of Asparagine-Linked Protein Glycosylation
  11. Conformational Analysis of C-Glycosides and Related Compounds: Programming Conformational Profiles of C- and O-Glycosides
  12. Synthetic Lipid A Antagonists for Sepsis Treatment
  13. Polysialic Acid Vaccines
  14. Synthetic Carbohydrate-Based Vaccines
  15. Chemsitry, Biochemistry, and Pharmaceutical Potentials of Glycosaminoglycans and Related Saccharides
  16. A New Generation of Antithrombotics Based on Synthetic Oligosaccharides

    Volume 2

  17. Sequencing of Oligosaccharides and Glycoproteins
  18. Preparation of Heterocyclic 2-Deoxystreptamine Aminoglycoside Analogues and Characterization of their Interaction with RNAs by Use of Electrospray Ionization Mass Spectrometry
  19. Glycosylation Analysis of a Recombinant P-Selectin Antagonist by High-pH Anion-Exchange Chromatography with Pulsed Electrochemical Detection (HPAEC/PED)
  20. Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans
  21. Thermodynamic Models of the Multivalency Effect
  22. Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes
  23. Glycosyltransferase Inhibitors
  24. RNA-Aminoglycoside Interactions
  25. Glycosylated Natural Products
  26. Novel Enzymatic Mechanisms in the Biosynthesis of Unusual Sugars
  27. Neoglycolipids: Identification of Functional Carbohydrate Epitopes
  28. A Preamble to Aglycone Reconstruction for Membrane-Presented Glycolipid Mimics
  29. Small Molecule Inhibitors of the Sulfotransferases
  30. Carbohydrate-Based Treatment of Cancer Metastasis
  31. N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-Influenza Agents
  32. Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents - The Biochemically Engineered N-Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine
  33. Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents - Glycosidated Phospholipids as a New Type of Antiproliferative Agents
  34. Glycoside Primers and Inhibitors of Glycosylation
  35. Carbohydrate-Based Drug Discovery in the Battle Against Bacterial Infections: New Opportunities Arising from Programmable One-Pot Oligosaccharide Synthesis

Subject Index

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Carbohydrate-based Drug Discovery
2 Volume Set
edited by Chi-Huey Wong

947 pages $524.00 + shipping
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