Pharmaceutical Book from C.H.I.P.S.

Chromatographic Methods in Clinical Chemistry and Toxicology
edited by Roger Bertholf

Chromatographic Methods in Clinical Chemistry and Toxicology aims to fill the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts.


  • Focuses almost exclusively on clinical relevance and applications
  • Devoted to clinical and toxicological applications of chromatographic methods will serve as an instructional and reference text


Quality Assurance, Quality Control and Method Validation in Chromatographic Applications

  • Definition of Quality Assurance and Quality Control
  • Professional Organizations
  • Internal Quality Assurance and Control
  • External Quality Assurance

Liquid Chromatographic-Mass Spectrometric Measurement of Anabolic Steroids

  • LC-MS Analysis of Synthetic Steroids or Animal Samples
  • LC-MS Analysis of Natural Androgens in Human Samples

High-performance Liquid Chromatography in the Analysis of Active Ingredients in Herbal Nutritional Supplements

  • St John’s Wort
  • Herbal Supplements with Digoxin-like Immunoreactivity
  • Herbal Remedies and Abnormal Liver Function Tests
  • Ginkgo Biloba
  • Echinacea
  • Valerian
  • Feverfew
  • Garlic
  • Ephedra (Ma Huang) and Related Drugs

Measurement of Plasma L-DOPA and L-Tyrosine by High-Performance Liquid Chromatography as a Tumor Marker in Melanoma

  • Melanogenesis
  • L-DOPA Alone
  • L-DOPA/L-Tyrosine Ratio

Hypersensitive Measurement of Proteins by Capillary Isoelectric Focusing and Liquid Chromatography-Mass Spectrometry

  • A Robust CIEF-RPLC Interface
  • First-Generation CIEF-RPLC-MS System for Proteins
  • Second-Generation CIEF-RPLC-MS System

Chromatographic Measurement of Transferrin Glycoforms for Detecting Alcohol Abuse and Congenital Disorders of Glycosylation

  • Transferrin Microheterogeneity
  • Carbohydrate-deficient Transferrin (CDT)
  • Congenital Disorders of Glycosylation (CDG)
  • Analytical Methods for Transferrin Microheterogeneity
  • Chromatographic Methods for CDT
  • Chromatographic Methods for CDG

Chromatographic Measurements of Catecholamines and Metanephrines

  • Total or individual assays
  • Analytical Measurements of Catecholamines and Metanephrines
  • Early Methods
  • Current Chromatographic Methods
  • Practical Considerations for the Stability of Urinary Catecholamines and Metanephrines During Storage

Chromatographic Measurement of Volatile Organic Compounds (VOCs)

  • Intended Use
  • Volatility of Compounds
  • Sample Collection, Handling and Storage
  • Headspace Gas Chromatographic Methods
  • Columns and Detectors
  • Identification, Quantitation and Confirmation
  • Ethanol and Other Volatile Alcohols
  • Inhalants and Screening for Multiple VOCs
  • Interpretation

Chromatographic Techniques for Measuring Organophosphorus Pesticides

  • Organophosphorus Pesticides (OPs)

Chromatographic Analysis of Nerve Agents

  • Neuromuscular Blockers
  • Paralytic Shellfish Poisoning: Saxitoxin

History and Pharmacology of c-Hydroxybutyric Acid

  • History of Illicit Use of GHB
  • Clinical Use of GHB in Humans
  • History of Illicit Use of GBL and 1,4BD
  • Distribution and Pharmacokinetics of GHB, GBL and 1,4BD
  • GHB Interpretation Issues and Post-mortem Production
  • Analysis for GHB, GBL and 1,4BD

Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection for Element Speciation: Clinical and Toxicological Applications

  • Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection
  • Analytical Applications of Clinical and Toxicological Relevance

Applications of Gas Chromatography-Mass Spectrometry to the Determination of Toxic Metals


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Chromatographic Methods in Clinical Chemistry
and Toxicology

edited by Roger Bertholf
2007 • 308 pages • $159.00 + shipping
Texas residents please add 6.75 % sales tax

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