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Food Science and Technology Reference
from C.H.I.P.S.

Clinical Evaluation of a Food Additive:
Assessment of Aspartame

edited by
Christian Tschanz et al


This useful book reviews and analyzes the rigorous scientific, regulatory, and clinical testing and evaluation applied to the widely used food additive aspartame. In one compact volume you gain access to extensive information illustrating the increased recognition by regulatory agencies of the usefulness of human studies in evaluating new food additives.

Features:

  • Provides an encyclopedic overview of the entire food additive evaluation process
  • Reviews determination of the acceptable food additive daily intake levels
  • Includes methods for estimation of food additive consumption levels
  • Describes the clinical studies used to evaluate aspartame's anecdotal medical complaints, including headaches, seizures, and allergic-type reactions
  • Allows chapters to be read independently
  • Contains an extensive index to facilitate quick access to specific information

Contents

Introduction: Regulatory Requirements for Human Studies. Clinical Studies with Food Additives. The Safety Assessment of Aspartame: Scientific and Regulatory Considerations. Acceptable Daily Intake and Estimation of Consumption.

Metabolism and Pharmacokinetic Studies in Humans: Metabolism and Pharmacokinetics of Radiolabeled Aspartame in Normal Subjects. Effects of Aspartame Ingestion on Plasma Aspartate, Phenylalanine, and Methanol Concentrations in Normal Adults. Effects of Aspartame Ingestion on Plasma Aspartate, Phenylalanine, and Methanol Concentrations in Potentially Sensitive Populations. Safety Evaluation in Pregnancy.

Tolerance in Various Populations: Tolerance in Healthy Adults and Children. Tolerance in Individuals with Diabetes. Tolerance in PKU Heterozygotes.Tolerance in Individuals with Renal Disease. Tolerance in Individuals with Liver Disease.

Evaluation of Anecdotal Medical Complaints: Postmarketing Surveillance of Anecdotal Medical Complaints. Evaluation of Headaches. Evaluation of Seizures. Evaluation of Behavior, Cognition, Mood, and Electroencephalograms in Normal Adults and Potentially Vulnerable Populations. Evaluation of Behavior, Cognition, and Electroencephalograms in PKU Heterozygotes. Evaluation of Children with Attention Deficit Disorder. Evaluation of Allergic-Type Reactions. Evaluation of Hunger, Food Intake, and Body Weight. Evaluation of Weight Control. Index.

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Clinical Evaluation of a Food Additive:
Assessment of Aspartame

edited by Christian Tschanz et al
308 pages $208.95 + shipping

Texas residents please add 6.75 % sales tax

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