Pharmaceutical Drug Dosage Book from C.H.I.P.S.

Controlled Release Dosage Form Design
by Cherng-ju Kim


  • Understand controlled release technology through a quantitative and mechanistic approach
  • Examines the common principles shared by several dosage forms regardless of the shape of the dosage form or the route of administration
  • Provides a unique tool to reverse engineer competing commercial products
  • Helps you choose the type of drug, excipient, and controlled release carrier materials BEFORE carrying out experiments

Controlled Release Dosage Form Design offers the tools needed to eliminate trial-and error and wasted time and money in controlled release dosage form design!

This pharmaceutical book helps the reader understand controlled release technology more quantitatively and mechanistically, thereby creatinga “visual” overall picture on the technology.

Controlled Release Dosage Form Design is an invaluable tool for all students and professionals in pharmaceutics, chemistry, chemical engineering, biology/biotechnology and medicine. If you are engaged or interested in the development of dosage forms, you will find this book invaluable.


  1. Conventional vs. Controlled Release
    • Advantages and Disadvantages
    • Pharmacokinetic Considerations of CRDF
    • Polymers as Drug Carriers
    • Classification of CRDFs
  2. Monolithic Matrix Controlled Systems
    • Dissolved Drugs
    • Dispersed Drugs
    • Drug-dissolution/diffusion Controlled Systems
  3. Membrane Controlled Systems
    • Constant Activity Reservoir
    • Non-Constant Activity Reservoir
    • Release of a Drug from a Membrane Reservoir into a Finite Volume
    • Unsteady State Analysis (Time-lag & Burst-effect)
    • Drug Release from Multi-layer Membrane Devices
    • Drug Release from Membrane-matrix Systems
    • Membrane Transport with Bio-conversion
  4. Swelling Controlled Systems
    • Mathematical Expression
    • Hydrogel Systems Polymer Dissolution Controlled Systems
    • Classification of Polymer Degradation and Erosion
    • Heterogeneous Erosion
    • Homogeneous Erosion
    • Acid Catalyzed Degradation
    • Autocatalyzed Degradation
    • Erosion/Drug Diffusion Controlled
    • Swelling/Erosion Controlled
    • Preparation of Biodegradable Microparticles
  5. Gradient Matrix Systems
    • Mathematical Expression
    • Tablets
    • Hydrogel Beads
    • Granules
    • Megaporous
  6. Ion Exchange Resin Systems
    • Exchange Process and Equilibrium
    • Ion Exchange Materials
    • Drug Release from Commercial Ion Exchange Resins
    • Highly Swellable Polyelectrolyte
    • Erodible Polyelectrolyte
    • Principle of Diffusion in the Ion Exchange Resin Matrix (Shrinking-core Model)
    • Drug Release in a Limited Volume
  7. Osmotically Controlled Systems
    • Osmosis
    • Elementary Osmotic Pump (OROS)
    • Solubility Modulated OROS
    • Microporous Osmotic Pump
    • Push-Pull
  8. Geometrically Modified Systems
    • Pie Shape, Perforated Coated, Donut (Coated/Uncoated) and Multi-hole
    • Frustum and Hemisphere
    • Multi-layer Tablet and Cylinder Systems Other Systems
    • Hydrodynamically Balanced Systems
    • Oral Time-controlled (Pulsatile) Release Systems
  9. Pharmacokinetic Considerations of CRDF Design
    • One-compartment Model
    • Two-compartment Model with Zero-order Release Kinetics
    • Pharmacokinetics on Transdermal Delivery Systems
    • In-vitro/In-vivo Correlation


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Controlled Release Dosage Form Design
by Cherng-ju Kim
280 pages • $228.95 + shipping
Texas residents please add 6.75 % sales tax

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