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Biopharmaceutical Drug Delivery Handbook
from C.H.I.P.S.

Delivery Technologies for Biopharmaceuticals
Peptides, Proteins, Nucleic Acids and Vaccines
edited by Lene Jorgensen

Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site.

Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products.

Includes:

  • challenges in delivery of biopharmaceuticals
  • novel formulation approaches for peptide and protein injectables
  • non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs
  • immune response, adjuvants and delivery systems for vaccines
  • several examples of delivery systems for different biopharmaceuticals
  • a critical assessment of delivery technologies for biopharmaceuticals

Contents

Introduction

  1. Challenges in Delivery of Biopharmaceuticals; the Need for Advanced Delivery Systems

Delivery of Biopharmaceuticals

  1. Novel Formulation Approaches for Peptide and Protein Injectables
  2. Novel Non-Injectable Formulation Approaches of Peptides and Proteins
  3. Chemical Vectors for Delivery of Nucleic Acid-Based Drugs
  4. Viral Technology for Delivery of Nucleic Acids
  5. The Innate Immune Responses, Adjuvants and Delivery Systems

Delivery Technologies for Biopharmaceuticals

  1. Lipid Nanoparticle-Based Systems for Delivery of Biomacromolecule Therapeutics
  2. Dendrimers in Delivery of Biopharmaceuticals

Peptides and Proteins

  1. Modification of Peptides and Proteins
  2. Nanocarriers for the Delivery of Peptides and Proteins
  3. Polymer-Based Delivery Systems for Oral Delivery of Peptides and Proteins
  4. Advanced Pulmonary Delivery of Peptides or Proteins Using Polymeric Particles

Nucleic Acids

  1. Polymer Microparticles for Nucleic Acid Delivery
  2. Pulmonary Delivery of Small Interfering RNA for Novel Therapeutics
  3. Lipid-Based Formulations for siRNA Delivery
  4. Cellular Bioavailability of Peptide Nucleic Acids (PNAs) Conjugated to Cell Penetrating Peptides
  5. DEAE-dextran-MMA Graft Copolymer for Non-Viral Delivery of DNA
  6. Liposomes in Adjuvant Systems for Parenteral Delivery of Vaccines
  7. Influenza Virosomes as Delivery Systems for Antigens
  8. GRAZAX: An Oromucosal Vaccine for Treating Grass Pollen Allergy with Immunotherapy

Final Comments

  1. Delivery Technologies for Biopharmaceuticals: A Critical Assessment

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Delivery Technologies for Biopharmaceuticals
Peptides, Proteins, Nucleic Acids and Vaccines
edited by Lene Jorgensen

2010 • 442 pages • $174.00 + shipping
Texas residents please add 6.75 % sales tax

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