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Industrial Pharmaceutical Book from C.H.I.P.S.

A Guide to Pharmaceutical Particulate Science
by Timothy M. Crowder

This book discusses key principles of particulate science and their practical applications.

Covers:

  • particulate material, its form and production
  • sampling from bodies of powder
  • particle size descriptors and statistics
  • behavior of particles
  • instrumental analysis
  • particle size measurement and synergy of adopted techniques
  • physical behavior of a powder
  • in vitro and in vivo performance criteria

Exploring the growth in knowledge of particle properties and the variety of technological advances in particle manufacture, A Guide to Pharmaceutical Particulate Science gives readers the tools they need to grasp the science and its use in the industry.

Features

  • Highlights the appropriate means to use this science for the benefit of industry
  • Provides a guide to key principles and their practical applications
  • Addresses the potential for error, misuse or abuse of data
  • Discusses particle characterization and its impact on regulatory submissions from formulation through toxicity and efficacy
  • Covers the application of particulate science in the formulation design, manufacturing, and control of medicines

Contents

  1. INTRODUCTION AND OVERVIEW
    • Situation Analysis
    • Quality of Published Data on Particle Size in Pharmaceuticals
    • The Future of Crystal Engineering
    • Chemistry and Pharmacy Regulatory Submissions
    • Misconceptions and Misunderstandings of Particulate Science
    • Powerful Methods Complementary to Particle Sizing
    • Integration of Particle Sizing Methods with their In-Use Situation
    • Adjacencies and Interactions Between Particles
    • Lessons from Other Industries
    • Pharmaceutical Particulate Science as a Core Educational Requirement
    • Particle Characterization and its Impact on Regulatory Submissions from Formulation through Toxicology and Efficacy

  2. PARTICULATE SYSTEMS: MANUFACTURE AND CHARACTERIZATION
    • States of Matter
    • Crystalline Solids
    • Crystal Symmetry
    • Euler's Relationship
    • Crystal Systems
    • Miller Indices
    • Space Lattices
    • Solid State Bonding
    • Isomorphs and Polymorphs
    • Enantiomorphs and Racemates
    • Crystal Habit
    • Crystal Imperfections
    • Methods of Particulate Production
    • Particulate Systems

  3. SAMPLING AND MEASUREMENT BIASES
    • Sampling Strategies
    • Statistical Analyses
    • Sampling Techniques
    • Segregation
    • Sampling
    • Sampling Errors
    • Preparation Errors
    • Particle Size Measurements Errors

  4. PARTICLE SIZE DESCRIPTIONS AND STATISTICS
    • Particle Size Descriptions
    • Particle Size Statistics
    • Mathematical Distributions
    • Applications

  5. BEHAVIOR OF PARTICLES
    • Physical Properties
    • Particle Adhesion
    • Particle Motion in Bulk Powders
    • Particle Motion in Gaseous Dispersions
    • Particle Motion in Liquid Media

  6. INSTRUMENTAL ANALYSIS
    • Direct Imaging
    • Indirect Imaging
    • Physical Methods of Particle Size Separation
    • Approaches to Calibration

  7. METHODS OF PARTICLE SIZE MEASUREMENT AND THEIR IMPORTANCE FOR SPECIFIC APPLICATIONS (INSTRUMENT SYNERGY)
    • An Essay on Measures of Diameters

  8. PARTICLE SIZE BEHAVIOR AND PHYSICAL BEHAVIOR OF A POWDER
    • Selection of the Appropriate Particle Size Expression
    • Powder Flow and Mixing
    • Dispersion
    • Granulation and Compression

  9. CLINICAL EFFECT OF PHARMACEUTICAL PARTICULATE SYSTEMS
    • Oral Delivery
    • Parenteral Delivery
    • Respiratory Delivery
    • Nasal Delivery
    • Transdermal and Topical Delivery
    • Ocular Delivery
    • Otic Delivery
    • Buccal and Sublingual Delivery
    • Rectal Delivery
    • Vaginal Delivery

References
Index

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A Guide to Pharmaceutical Particulate Science
by Timothy M. Crowder
241 pages $348.95 + shipping
Texas residents please add 6.75 % sales tax

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