Microbiology book from C.H.I.P.S.

Handbook on Clostridia
edited by Peter Duerre

  • Discusses the industrial fermentation of Clostridia
  • Describes biotechnologically important species
  • Covers recombinant Clostridia in various applications
  • Reviews therapeutic applications

Handbook on Clostridia takes a global approach by presenting information on both Clostridia of biotechnological importance and Clostridia of medical importance. Experts in the field summarize methods, physiology, medical significance, regulation, ecosystems, genomics, and current and potential applications.

Handbook on Clostridia provides a comprehensive resource on the complete field of Clostridium, and serves as a compilation of critical reviews on the advantages of using Clostridia for new medical and biotechnological applications. It is a valuable reference for every specialist or researcher involved in this field.


  1. Methods
    • Species and strain identification methods
    • Quantitative proteome analysis of clostridia
    • Gene cloning in clostridia
    • Gene analysis of clostridia
    • Anoxic testing and purification of enzymes

  2. Metabolic Pathways and Transport Systems
    • Degradation of polymers: cellulose, xylan, pectin, starch
    • Genetic organisation and regulation of hexose and pentose utilization in the clostridia
    • Carbohydrate uptake by the phosphotransferase system and other mechanisms
    • Special clostridial enzymes and fermentation pathways
    • Degradation of heterocyclic compounds
    • Nitrogen assimilation in the clostridia
    • Nitrogen fixation
    • Clostridial potassium transport systems
    • Transport of phosphate

  3. Cellular Components and Medical Aspects
    • Membranes lipids of clostridia
    • Adhesins
    • Clostridial toxins versus other bacterial toxins
    • Clostridial enterotoxins
    • Clostridial cytotoxins
    • Membrane active toxins
    • Clostridial neurotoxins
    • Clostridial diseases of domestic animals

  4. Regulatory Mechanisms
    • Two-component signal transduction systems in the clostridia
    • Comparative genomic analysis of signal transduction proteins in clostridia
    • Regulation of catabolic gene systems
    • RNA polymerase and alternative s factors
    • Transposable genetic elements of the clostridia

  5. Complex Regulatory Networks
    • Sporulation (morphology) of the clostridia
    • Sporulation in clostridia (genetics)
    • Formation of solvents in clostridia

  6. Special Groups and Ecosystems
    • Bacteriophages of Clostridium
    • Acetogenic clostridia
    • Halophilic clostridia
    • Syntrophism among clostridiales
    • Ecology and activity of clostridia in the intestine of mammals

  7. Novel Developments and Applications
    • Industrially relevant fermentations
    • Metabolic engineering of solventogenic clostridia
    • Biodegradation of hazardous materials by clostridia
    • Clostridial collagenase in wound repair
    • Clostridia as production systems for prokaryotic and eukaryotic proteins of therapeutic value in tumor treatment


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Handbook on Clostridia
edited by Peter Duerre
2005 920 pages $198.95 + shipping
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