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Pharmaceutical Book from C.H.I.P.S.

In Silico Technologies in Drug Target Identification and Validation
by Darryl Leon

In Silico Technologies in Drug Target Identification and Validation addresses the challenge of testing a growing number of new potential targets and reviews currently available in silico approaches for identifying and validating these targets.

Features:

  • Presents the most recent trends based on significant advances made in genomics, proteomics, and bioinformatics since the 1970s
  • Examines genomic correlations between different organisms and various models that simulate disease progression in humans
  • Details the components of BioIT hardware configuration and architecture requirements, a key tool for supporting in silico research
  • Reviews the numerous tools, initiatives, projects, and standards for ontologies and how they can be used in the drug discovery process
  • Provides examples and tables to illustrate the use of a particular technology as well as recommended books, journal articles, and Web sites for further information

Contents

Target Identification

  • Pattern Matching
  • Tools for Computational Protein Annotation and Functional Assignment
  • The Impact of Genetic Variation on Drug Discovery and Development
  • Mining of Gene Expression Data

Target Validation

  • Text Mining
  • Pathways and Networks
  • Molecular Interactions: Learning from Protein Complexes
  • In Silico siRNA Design
  • Predicting Protein Subcellular Localization Using Intelligent Systems
  • Three-Dimensional Structures in Target Discovery and Validation

Recent Trends

  • Comparative Genomics
  • Pharmacogenomics
  • Target Identification and Validation Using Human Simulation Models
  • Using Protein Targets for In Silico Structure-Based Drug Discovery

Computational Infrastructure

  • Database Management
  • BioIT Hardware Configuration
  • BioIT Architecture: Software Architecture for Bioinformatics Research
  • Workflows and Data Pipelines
  • Ontologies

Index

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In Silico Technologies in Drug Target
Identification and Validation

by Darryl Leon
2006 504 pages $148.95 + shipping
Texas residents please add 6.75 % sales tax

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