Metabolic Drug Interactions

by René H. Levy et al

This volume brings together the large body of recent research on metabolic drug interactions and their relevance in the treatment of diseases.

Metabolic Drug Interactions focuses on human metabolic enzyme systems that have been shown in vitro to be predictive of drug interactions.

Major sections present information on specific therapeutic classes of drugs as substrates, inhibitors, and inducers of metabolic enzymes. Other chapters discuss the clinical and pharmacoeconomic implications of metabolic drug interactions and the significance of in vitro metabolic studies in new drug development.

Metabolic Drug Interactions is an outstanding pharmaceutical reference.

Contents

1. Prediction of Drug Interactions from In Vitro Studies: Basic Principles
   1. Metabollicaly-Based Drug-Drug Interactions: Principles and Mechanisms
   2. From In Vitro to In Vivo: An Academic Perspective
   3. Industrial Viewpoint: Application of In Vitro Drug Metabolism in Various Phases of Drug Development
   4. Regulatory Viewpoint: Prediction of Drug Interactions from In Vitro Studies

2. Enzymes and Transporters
   5. Cytochromes P450: Historical Overview
   6. CYP1A
   7. CYP2C
   8. CYP2D6
   9. CYP2E1
   10. CYP3A
   11. P-Glycoprotein
   12. Other CYP: 2A6, 2B6, 4A
   13. UDP-Glucuronosyltransferases
   14. Glutathione S-Transferases
   15. Sulfotransferases and Methyltransferases
   16. Epoxide Hydrolases

3. Drugs as Substrates of Metabolic Enzymes
   Treatment of CNS Diseases
   17. Anticonvulsants
   18. Antidepressants
   19. Antipsychotics
   20. Sedative-Hypnotic and Anxiolytic Agents
   21. Volatile, Intravenous, and Local Anesthetics
   22. Opiod Analgesics
   23. Agents for the Treatment of Migraine, Parkinson's, and Alzheimer's Diseases

   Treatment of Cardiovascular Diseases

   24. Calcium Channel Blockers
   25. β-Adrenoreceptor Antagonists
   26. Angiotensin II Antagonists, ACE Inhibitors, and Diuretics
   27. Cholesterol-Lowering Agents and Cardiac Glycosides
   28. Antiarrhythmics
   29. Oral Anticoagulants

   Treatment of Microbial Diseases

   30. Oral Antifungals
   31. Antivirals

   Treatment of Inflammation

   32. H₁-Receptor Antagonists
   33. Analgesics-Antipyretics
   34. Nonsteroidal Antiinflammatory Drugs
   35. Methylxanthines

   Treatment of Other Diseases

   36. H₂-Antagonists, Proton-Pump Inhibitors, and Antiemetics
   37. Immunosuppressive Agents
   38. Estrogens and Progestins
   39. Hypoglycemic Agents
   40. Antineoplastic Agents

4. Drugs as Inhibitors of Metabolic Enzymes
   Treatment of CNS Diseases
   41. Anticonvulsants
   42. Antidepressants
   43. Neuroleptics and Antipsychotics

   Treatment of Cardiovascular Diseases

   44. Calcium Channel Blockers
   45. Antiarrythmics

   Treatment of Microbial Diseases

   46. Antimicrobials and Antiparasitics
   47. Antifungals
   48. Protease Inhibitors

   Treatment of Other Diseases

   49. H₂-Receptor Antagonists
   50. Inhibitors in the Diet: Grapefruit Juice-Drug Interactions

5. Drugs as Inducers of Metabolic Enzymes
   51. Phenobarbital, Phenytoin, and Carbamazepine
   52. Rifampin, Dexamethasone, and Omeprazole
   53. Isoniazid and Ethanol

6. Clinical Considerations
   54. Clinical and Pharmacoeconomic Significance of Metabolic Drug Interactions
   55. Pharmacist Management of Drug Interactions
   56. Interactions in the Elderly

7. Appendix
   • Other Drugs
   • Drug Interaction Index
   • General Index

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