This book ensures that the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, will receive a comprehensive summary and critical overview of a topic of high current interest written by leading international experts.

Contents

1. History of Cisplatin as an Anticancer Drug
   
   • Early Structural Studies of Cisplatin-Nucleotide Complexes
     
   • Scope of This Review
   
   
2. Development of Cisplatin Derivatives
   
   • Platinum(II) and Platinum(II) Amine Derivatives
     
   • Non-Amine-Based Platinum(II) Derivatives
     
   • trans-Platinum(IV) Derivatives
     
   • Dinuclear Platinum(II) Derivatives
   
   
3. Interaction of Cisplatin and Related Complexes with DNA
   
   • Kinetics and Order of Cisplatin Binding to Adjacent Purines in DNA
     
   • Sequence Specificity of Cisplatin and Carboplatin in Vitro and in Vivo
     
   • DNA Targets for Cisplatin may Reflect its Ease of Removal (repair)
     
   • Cisplatin Interaction with Telomeres and Telomerase
   
   
4. Structural Studies of Platinum-DNA Complexes
   
   • Solution and Crystal Structures of Intrastrand Cross-Linked Duplex DNAs
     
   • Solution Structures of Interstrand Cross-Linked Duplex DNAs
     
   • Structural Studies of Other Platinum DNA Adducts
     
   • Structual Transitions and Stability of the Cisplatin-DNA Adducts
   
   
5. Interacions of Platinated DNA with Cellular Proteins
   
   • Discovery of Structure-Specific Recognition Protein SSRP1 and its Interaction With Cisplatin-Modified DNA
     
   • HMG-Domain Proteins Bind Specifically to Cisplatin Modified DNA

Index

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