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Metalpharmaceuticals and DNA Interactions
from C.H.I.P.S.

Metallopharmaceuticals
DNA Interactions
edited by M.J. Clarke
and P.J. Sadler

This book ensures that the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, will receive a comprehensive summary and critical overview of a topic of high current interest written by leading international experts.

Contents

  1. History of Cisplatin as an Anticancer Drug
    • Early Structural Studies of Cisplatin-Nucleotide Complexes
    • Scope of This Review

  2. Development of Cisplatin Derivatives
    • Platinum(II) and Platinum(II) Amine Derivatives
    • Non-Amine-Based Platinum(II) Derivatives
    • trans-Platinum(IV) Derivatives
    • Dinuclear Platinum(II) Derivatives

  3. Interaction of Cisplatin and Related Complexes with DNA
    • Kinetics and Order of Cisplatin Binding to Adjacent Purines in DNA
    • Sequence Specificity of Cisplatin and Carboplatin in Vitro and in Vivo
    • DNA Targets for Cisplatin may Reflect its Ease of Removal (repair)
    • Cisplatin Interaction with Telomeres and Telomerase

  4. Structural Studies of Platinum-DNA Complexes
    • Solution and Crystal Structures of Intrastrand Cross-Linked Duplex DNAs
    • Solution Structures of Interstrand Cross-Linked Duplex DNAs
    • Structural Studies of Other Platinum DNA Adducts
    • Structual Transitions and Stability of the Cisplatin-DNA Adducts

  5. Interacions of Platinated DNA with Cellular Proteins
    • Discovery of Structure-Specific Recognition Protein SSRP1 and its Interaction With Cisplatin-Modified DNA
    • HMG-Domain Proteins Bind Specifically to Cisplatin Modified DNA

Index

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Metallopharmaceuticals I
DNA Interactions
edited by M.J. Clarke and P.J. Sadler
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