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Biopharmaceuticals Book from C.H.I.P.S.

Molecular Biopharmaceutics
Aspects of drug characterization, drug delivery and dosage
form evaluation
edited by Bente Steffansen

Molecular Biopharmaceutics's focus is on describing the interplay between the chemistry of drug molecules and membrane transporters.

It also aims to guide researchers in setting up experiments that may help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery.

Starting with an introduction to the topic, Molecular Biopharmaceutics then considers the following:

  • physico-chemical characterization of drug candidates
  • membrane transport of drug candidates
  • describing and predicting bioavailability

Contents

1. Physicochemical characterisation of drug candidates

  • Acid/base properties, solubility and distribution of drug candidates
  • Mechanisms of decomposition of drug candidates
  • Kinetics of decomposition in aqueous solution
  • Chemical approaches to improving bioavailability properties of oral drug candidates
  • Preformulation in the industry step by step
2. Membrane transport of drug candidates
  • Structure and function of absorption barriers
  • Passive diffusion of drug substances: the concepts of flux and permeability
  • Carrier-mediated transport kinetics
  • Classification of human transporters
  • Absorptive transporters
  • Efflux transporters
  • Preclinical evaluation of drug transport
3. Describing and predicting bioavailability
  • In vitro dissolution
  • The Biopharmaceutics Classification System in drug discovery and development
  • Biosimulation studies
Index

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Molecular Biopharmaceutics
Aspects of drug characterization, drug delivery
and dosage form evaluation
edited by Bente Steffansen

2010 • 371 pages • $219.00 + shipping
Texas residents please add 6.75 % sales tax

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