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Nimesulide
Actions and Uses
by K. D. Rainsford

Nimesulide provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents.

Contents

The Discovery, Development and Novel Actions of Nimesulide

  • Discovery of R-805 - Nimesulide
  • Chemical Synthesis
  • Development of Nimesulide
  • Physical and Chemical Properties
  • Chemical Analysis
  • Chemical Reactions of Nimesulide
  • Versatile Folmulations
  • Novel "Non-Pain" Uses of Nimesulide
  • Miscellaneous Uses

Pharmacokinetics of Nimesulide

  • Physiochemical Factors Governing the Oral Bioavailability of Nimesulide
  • Animal Pharmacokinetics
  • Pharmacokinetics in Humans

Pharmaceutical Formulations of Nimesulide

  • Formulations for Topical Application
  • Formulations for Systemic Administration
  • Oral Cyclodextrin Formulations
  • Oral Modified-Release Formulations
  • Generic Formulations

Pharmacological Properties of Nimesulide

  • In Vivo Pharmacological Actions
  • Mechanisms of Action of Nimesulide on Pathways of Inflammation Effects of Nimesulide on Arachidonic Acid Metabolism In Vitro, Ex Vivo and In Vivo
  • Structural Aspects of Cyclooxygenase (COX) Activity and COX-2 Inhibition by Nimesulide
  • Nimesulide and Neutrophil functional Responses
  • Analgesic Actions of Nimesulide in Animals and Humans
  • Actions on Joint Destruction in Arthritis
  • Regulation by Eicosanoids of Cartilage-Synovial-Leucocyte Interactions
  • In Vivo Effects of Nimesulide on Cartilage and Bone in Experimental Model Systems
  • Actions of Nimesulide on Cartilage Degradation In vitro

Clinical Applications of Nimesulide in Pain, Arthritic Conditions and Fever

  • NSAIDs: The Survivors from the Laboratory
  • Osteoarthritis: A Leading Target for NSAIDs
  • Nimesulide in the Treatment of Osteoarthritis
  • Miscellaneous Rheumatic Conditions
  • The Analgesic Properties of Nimesulide in Inflammatory Pain
  • Nimesulide in the Treatment of Primary Dysmenorrhoea and Other Gynaecological Conditions
  • NSAIDs in Sports Medicine
  • Acute Pain Models and Conditions
  • Adverse Events Encountered in Clinical Trials

Adverse Reactions and Their Mechanisms from Nimesulide

  • Nimesulide Safety Profile from Spontaneous Reporting
  • Nimesulide Safety from Epidemiological and Population Studies
  • Meta-Analysis and Systematic Reviews of Adverse Reactions from Clinical Trials
  • Gastrointestinal Tolerance of Nimesulide Compared with other NSAIDs: Clinical Studies
  • Clinical Aspects of Nimesulide-Related Hepatic Reactions from Published Case Reports
  • Mechanisms of Toxic Reactions

Index

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Nimesulide
Actions and Uses
by K. D. Rainsford

2005 433 pages $168.00 + shipping
Texas residents please add 6.75% sales tax

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