edited by Janos Zempleni
and Krishnamurti Dakshinamurti
Nutrients and Cell Signaling fully delineates the role of nutrients in cell signaling. The text emphasizes broad concepts and covers all major groups of nutrients. Contributors discuss the role of carbohydrates, amino acids, lipids, vitamins, minerals, and trace elements in essential processes such as cell proliferation, immune function, and DNA repair.
Nutrients and Cell Signaling provides select examples organized under these contemporary research areas:
- Nuclear receptors, transcription factors, and signaling cascades
- Amino acids, lipids, and glycation
- Insulin release, signaling, and insulin resistance
- Calcium-dependent signaling
- Feeding and nutrient homeostasis
Nutrients and Cell Signaling answers the need in the post-genomic era, for an authoritative resource that provides an in-depth understanding of how these complex and dynamic biomolecular networks control cell function. Those professionals and students in molecular biology, nutrition, biochemistry, as well as any branch involved with cell signaling and function will find this book to be an invaluable tool in promoting both understanding and further inquiry.
Features:
- Offers examples for the roles of nutrients in essential processes such as cell proliferation, immune function, and DNA repair, including novel information on the role of histone biotinylation
- Describes the roles of nutrients in epigenetic control mechanisms
- Offers a fresh look at the mechanics of insulin release, signaling and insulin resistance
- Discusses cellular calcium influx and release, and their control by various intracellular metabolites
Contents:
- Nuclear receptors, transcription factors, and signaling cascades
- NFkB-dependent signaling pathways
- Steroid receptors and dietary ligands
- Retinoid signaling
- Regulation of cytokines and immune function by 1,25-dihydroxyvitamn D3 and its analogues
- Vitamin D regulated pathways: impact on cell proliferation, differentiation, and apoptosis
- Effects of nutrient deprivation on the expression of growth-arrest genes
- Mechanisms for dietary regulation of nitric oxide synthesis in mammals
- The roles of thioredoxin reductases in cell signaling
- Roles for biotinylation of histones in chromatin structure
- Amino acids, lipids, and glycation
- Nutrient signaling to muscle and adipose tissue by leucine
- Anabolic effects of amino acids and insulin in the liver
- Amino acid-sensing of mTOR signaling
- Alterations in glutamate trafficking and signal transduction pathways in hyperammonemia
- The influence of lipids on nuclear protein import, cell growth and gene expression
- Isoprenoid regulation of the expression of RAS and RAS-related proteins
- Amino acid signaling and the control of autophagy
- A nutrient-sensing hexosamine signaling pathway
- Insulin release, signaling, and insulin resistance
- Insulin release
- Metabolic actions of the glucagon-like peptides
- Calcium-dependent signaling
- Control of intracellular calcium levels
- Calcium-mediated signaling of neurons in the physiological and diseased state: role of endoplasmic reticulum
- Feeding and nutrient homeostasis
- Within-meal feedback signaling
- The arcuate nucleus: its special place in the brain networks that control feeding behavior
Index
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