Pharmaceutical Applications of Raman Spectroscopy provides the basic theory of Raman effect and instrumentation, and then addresses a wide range of pharmaceutical applications.
Current applications that are routinely used as well as those with promising potential are covered.
Applications cover a broad range from discovery to manufacturing in the pharmaceutical industry and include identifying polymorphs, monitoring real-time processes, imaging solid dosage formulations, imaging active pharmaceutical ingredients in cells, and diagnostics.
Contents
1. Introduction to Raman Spectroscopy
- History of Raman Spectrodcopy
- The Principle of Raman Spectroscopy
- An Example of Simpel Raman Spectrum: Raman Spectrum of Water
- Characteristics of Raman Spectroscopy
- The Classic Theory fo Raman Effect
- The Quantum Theory of Raman Scattering
- Ctross Section
- Relevance to Pharmaceuticals
- Resonance Raman Effect
- Instrumentation for Raman Spectroscopy
2. Quantitative Analysis of Solid Dosage Formulations by Raman Spectroscopy
- Quantitative Analysis
- Instrumental Parameters
- Experimental Considerations
- Nonstandard Samples
3. Surface Enhanced Resonance Raman Scatttering
- Theory
- The Exper4imental Setup
- Examples of SERS/SERRS Assays
4. Raman Spectroscopy for Identifying Polymorphs
- Introduction of Polymorphism
- Instrumental Methods of Polymorph Characterization
- Polymorph Screening
- Process Control
- Polymorph Quantitation
- Calibration Set and Sample Preparation
- Quantitation
- Intellectual Property
5. Raman Spectroscopy for Monitoring Real-time Processes in the Pharmaceutical Industry
- A Brief History of Raman Spectroscopy
- Basic Theory of Raman Spectroscopy
- General Instrumentation for Raman Spectroscopy
- The Choice-Dispersive or FT?
- Process Analysis and PAT
- Why Choose Raman as a PAT Tool? The Need for Raman
- Data Analysis
- Applications
6. Raman Chemical Imaging of Solid Dosage Formulations
- Methods for Chemcial Imaging
- Data Analysis
- Experimental
- Applications
7. In vivo Raman Confocal Microspectroscopy of Skin
8. Raman Microspectrscopy and Imgaging of Active Pharmaceutical Ingredients in Cells
- Current Appraoches to Drug Imaging
- Raman Spectroscopy and Raman Imaging
- Raman Microspectroscopy and Imaging for Drug Research
- Raman Intensity, Fluorescence Background, and SNR
- Techniques to Improve SNR in Raman Imaging
- Enhanced Raman Images with Postprocessing
- Raman Imaging of Intracellular Distribution of Paclitaxel in Living Cells
- Raman Imaging of Intracellular Distribution of Sulindac Sulfide in Fixed Cells
Index
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