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Drugs and Pharmaceutical Sciences Handbook
from C.H.I.P.S.

Pharmaceutical Extrusion Technology
edited by
Isaac Ghebre-Sellassie
and Charles Martin

Pharmaceutical Extrusion Technology details

  • extruder hardware and controls
  • screw and die designs
  • process definition and troubleshooting of single- and twin-screw extrusion processes
  • the application of extrusion technology in pharmaceutical dosage form development
  • qualification and validation of extruders and extrusion processes

In-depth descriptions and analyses of the key parameters of extruders and extrusion processes - highlighting the applicability of melt extrusion in pharmaceutical drug development and manufacturing, including controlled release, dissolution rate and bioavailability enhancement, and granulation technology are provided. All the technical information necessary to develop and market pharmaceutical dosage forms that meet the current quality and regulatory requirements are brought together here.

Contents

  1. Historical Overview
  2. Extruder Design
  3. Single-Screw Extrusion and Screw Design
  4. Twin-Screw Extrusion and Screw Design
  5. Die Design
  6. Material Handling and Feeder Technology
  7. Rheology and Torque Rheometers
  8. Process Design
  9. Melt Pelletization
  10. Melt-Extruded Controlled-Release Dosage Forms
  11. Shape Extrusion
  12. Film, Sheet, and Laminates
  13. Melt-Extruded Molecular Dispersions
  14. Extrusion/Spheronization
  15. Twin-Screw Wet Granulation
  16. Installation, Commissioning, and Qualification
  17. Controls and Instrumentation
  18. Future Trends

Index

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Pharmaceutical Extrusion Technology
edited by Isaac Ghebre-Sellassie and Charles Martin
400 pages $298.95 + shipping
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