Second Edition
edited by Werner Kalow
Pharmacogenomics gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.
Features:
- Highlights the most recent applications, techniques, and technologies that may enable researchers to tailor drug treatment regimens to individual patients with the aid of genomic information
- Considers not only individual differences in susceptibility to adverse drug effects, but genetic differences in drug efficacy
- Uses a multitude of examples to clarify gene-drug interactions
- Examines the role and mechanisms of drug metabolism, receptors, transporters, ion channels, interethnic differences, and regulatory components as seen from an FDA perspective
- Presents modern approaches to gene expression and its detection via serial analysis and microarray
Contents
- Historical Aspects of Pharmacogenetics
- Pharmacogenomics and the Promise of Personalized Medicine
- Current Status of Pharmacogenomics
- Drug Metabolism
- Receptors
- Pharmacogenetics and Drug Transporters
- Variability of Induction Processes
- Pharmacogenetics and Cardiac Ion Channels
- Interethnic Differences in Drug Response
- Clinical Viewpoints
- Regulatory Perceptions
- Methodologies in Genetics and Genomics
- Tools of the Trade: The Technologies and Challenges of Pharmacogenomics
- Technologies for the Analysis of Single Nucleotide Polymorphisms
- Molecular Diagnostics and Development of Biotechnology-based Diagnostics
- Metabonomics
- MALDI-TOF MS: Application in Genomics
- Measuring Gene Expression: Transcriptional Insights into Functional Biology
- From Genotype to Phenotype
- Proteomics
- Haplotype Structure
- Pharmacoepigenetics: From Basic Epigenetics to Therapeutic Applications
- Bioinformatics: Aims and Methodologies of a New Discipline
- Internet Rsources
- Applied Bioinformatics
- Genetics of Common Diseases
- Mapping of Disease Loci
- Positional Cloning and Disease Gene Identification
- Genome Variation Influencing Gene Copy Number and Disease
Index