Pharmacogenomics gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.

Features:

• Highlights the most recent applications, techniques, and technologies that may enable researchers to tailor drug treatment regimens to individual patients with the aid of genomic information
• Considers not only individual differences in susceptibility to adverse drug effects, but genetic differences in drug efficacy
• Uses a multitude of examples to clarify gene-drug interactions
• Examines the role and mechanisms of drug metabolism, receptors, transporters, ion channels, interethnic differences, and regulatory components as seen from an FDA perspective
• Presents modern approaches to gene expression and its detection via serial analysis and microarray

Contents

• Historical Aspects of Pharmacogenetics
• Pharmacogenomics and the Promise of Personalized Medicine
• Current Status of Pharmacogenomics
• Drug Metabolism
• Receptors
• Pharmacogenetics and Drug Transporters
• Variability of Induction Processes
• Pharmacogenetics and Cardiac Ion Channels
• Interethnic Differences in Drug Response
• Clinical Viewpoints
• Regulatory Perceptions
• Methodologies in Genetics and Genomics
• Tools of the Trade: The Technologies and Challenges of Pharmacogenomics
• Technologies for the Analysis of Single Nucleotide Polymorphisms
• Molecular Diagnostics and Development of Biotechnology-based Diagnostics
• Metabonomics
• MALDI-TOF MS: Application in Genomics
• Measuring Gene Expression: Transcriptional Insights into Functional Biology
• From Genotype to Phenotype
• Proteomics
• Haplotype Structure
• Pharmacoepigenetics: From Basic Epigenetics to Therapeutic Applications
• Bioinformatics: Aims and Methodologies of a New Discipline
• Internet Rsources
• Applied Bioinformatics
• Genetics of Common Diseases
• Mapping of Disease Loci
• Positional Cloning and Disease Gene Identification
• Genome Variation Influencing Gene Copy Number and Disease

Index

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