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Pharmaceutical Book from C.H.I.P.S.

Pharmacogenomics
Second Edition
edited by Werner Kalow

Pharmacogenomics gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.

Features:

  • Highlights the most recent applications, techniques, and technologies that may enable researchers to tailor drug treatment regimens to individual patients with the aid of genomic information
  • Considers not only individual differences in susceptibility to adverse drug effects, but genetic differences in drug efficacy
  • Uses a multitude of examples to clarify gene-drug interactions
  • Examines the role and mechanisms of drug metabolism, receptors, transporters, ion channels, interethnic differences, and regulatory components as seen from an FDA perspective
  • Presents modern approaches to gene expression and its detection via serial analysis and microarray

Contents

  • Historical Aspects of Pharmacogenetics
  • Pharmacogenomics and the Promise of Personalized Medicine
  • Current Status of Pharmacogenomics
  • Drug Metabolism
  • Receptors
  • Pharmacogenetics and Drug Transporters
  • Variability of Induction Processes
  • Pharmacogenetics and Cardiac Ion Channels
  • Interethnic Differences in Drug Response
  • Clinical Viewpoints
  • Regulatory Perceptions
  • Methodologies in Genetics and Genomics
  • Tools of the Trade: The Technologies and Challenges of Pharmacogenomics
  • Technologies for the Analysis of Single Nucleotide Polymorphisms
  • Molecular Diagnostics and Development of Biotechnology-based Diagnostics
  • Metabonomics
  • MALDI-TOF MS: Application in Genomics
  • Measuring Gene Expression: Transcriptional Insights into Functional Biology
  • From Genotype to Phenotype
  • Proteomics
  • Haplotype Structure
  • Pharmacoepigenetics: From Basic Epigenetics to Therapeutic Applications
  • Bioinformatics: Aims and Methodologies of a New Discipline
  • Internet Rsources
  • Applied Bioinformatics
  • Genetics of Common Diseases
  • Mapping of Disease Loci
  • Positional Cloning and Disease Gene Identification
  • Genome Variation Influencing Gene Copy Number and Disease

Index

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Pharmacogenomics
edited by Werner Kalow
2005 696 pages $248.95 + shipping
Texas residents please add 6.75 % sales tax

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