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Pharmaceutical Process Chemistry Handbook
from C.H.I.P.S.

Pharmaceutical Process Chemistry
edited by Takayuki Shioiri

Covering the whole area of process chemistry in the pharmaceutical industry, Pharmaceutical Process Chemistry provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances.

Application-oriented and well structured, the book includes recent examples of excellent industrial production of active pharmaceutical ingredients.

Contents

  1. From Milligrams to Tons: The Importance of Synthesis and Process Research in the Development of New Drugs
  2. Design of Dynamic Salt Catalysts Based on Acid–Base Combination Chemistry
  3. Asymmetric Oxidation with Hydrogen Peroxide, an Effective and Versatile Oxidant
  4. Development of Palladium Catalysts for Chemoselective Hydrogenation
  5. Silicon-Based Carbon–Carbon Bond Formation by Transition Metal Catalysis
  6. Direct Reductive Amination with Amine Boranes
  7. Industrial Synthesis of Perfluorinated Building Blocks by Liquid-Phase Direct Fluorination
  8. Cross-Linked Enzyme Aggregates as Industrial Biocatalysts
  9. Application of Whole-Cell Biocatalysts in the Manufacture of Fine Chemicals
  10. Process Development of Amrubicin Hydrochloride, an Anthracycline Anticancer Drug
  11. Process Development of HIV Integrase Inhibitor S-1360
  12. An Efficient Synthesis of the Protein Kinase Cβ Inhibitor JTT-010
  13. Process Development of Oral Carbapenem Tebipenem Pivoxil, TBPM-PI
  14. Some Progress in Organic Synthesis of Pharmaceuticals in China
  15. The Use of Continuous Processing to Make AZD 4407 Intermediates
  16. Sustainable Processes Based on Enzymes Enabling 100% Yield and 100% ee Concepts
  17. Development of a Novel Synthetic Method for RNA Oligomers
  18. Process Research with Explosive Reactions
  19. Scientific Strategy for Optical Resolution by Salt Crystallization: New Methodologies for Controlling Crystal Shape, Crystallization, and Chirality of Diastereomeric Salt
  20. Development of New Drug and Crystal Polymorphs
  21. Development of LIPOzymes Based on Biomembrane Process Chemistry
  22. Matching Chemistry with Chemical Engineering for Optimum Design and Performance of Pharmaceutical Processing
  23. The Integration of Safety, Health, and Environmental Considerations into Process Development

Index

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Pharmaceutical Process Chemistry
edited by Takayuki Shioiri
2011 • 526 pages • $209.00 + shipping
Texas residents please add 6.75 % sales tax

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