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Physicochemical Principles of Pharmacy
Fourth Edition
by Alexander T. Florence

Physicochemical Principles of Pharmacy provides the physiochemical background to the design and use of pharmaceutical dosage forms.

Physicochemical Principles of Pharmacy goes beyond the introductory aspects of the subject to show how basic physiochemical principles are essential to an understanding of every aspect of drug action, from the dosage form to the site of action in the body.



  • Crystal Structure
  • Crystal Form
  • Polymorphism
  • Crystal Hydrates
  • Dissolution of Solid Drugs
  • Biopharmaceutical Importance of Particle Size
  • Wetting of Powders
  • Solid Dispersions

Gases and Volatile Agents

  • Pressure Units
  • Ideal and Nonideal Gases
  • Vapour Pressure
  • Solubility of Gases in Liquids
  • The Solubility of Gases in Blood and Tissues

Physicochemical Properties of Drugs in Solution

  • Concentration Units
  • Thermodynamics-A Brief Introduction
  • Activity and Chemical Potential
  • Osmotic Properties of Drug Solutions
  • Ionisation of Drugs in Solution
  • Diffusion of Drugs in Solution

Drug Stability

  • The Chemical Decomposition of Drugs
  • Kinetics of Chemical Decomposition in Solution
  • Solid Dosage Forms: Kinetics of Chemical Decomposition
  • Factors Influencing Drug Stability
  • Stability Testing and Prediction of Shelf-Life

The Solubility of Drugs

  • Definitions
  • Factors Influencing Solubility
  • Measurement of Solubility
  • The Solubility of Parameter
  • Solubility in Mixed Solvents
  • Cyclodextrins as Solubilising Agents
  • Solubility Problems in Formulation
  • Partitioning
  • Biological Activity and Partition Coefficients: Thermodynamic Activity and Ferguson's Principle
  • Using Log P


  • Amphipathic Compounds
  • Surface and Interfacial Properties of Surfactants
  • Micellisation
  • Liquid Crystals and Surfactant Vesicles
  • Properties of Some Commonly Used Surfactants
  • Solubilisation

Emulsions, Suspensions and Other Disperse Systems

  • Classification of Colloids
  • Colloid Stability
  • Emulsions
  • Suspensions
  • Applications of Colloid Stability Theory to Other Systems
  • Foams and Defoamers

Polymers and Macromolecules

  • Pharmaceutical Polymers
  • Water-Soluble Polymers
  • General Properties of Polymer Solutions
  • Some Water-Soluble Polymers Used in Pharmacy and Medicine
  • Water-Insoluble Polymers and Polymer Membranes
  • Some Applications of Polymeric Systems in Drug Delivery

Drug Absorption and Routes of Administration

  • Biological Membranes and Drug Transport
  • The Oral Route and Oral Absorption
  • Buccal and Sublingual Absorption
  • Intramuscular and Subcutaneous Injection
  • Transdermal Delivery
  • Medication of the Eye and the Eye as a Route for Systemic Delivery
  • The Ear
  • Absorption from the Vagina
  • Inhalation Therapy
  • The Nasal Route
  • Rectal Absorption of Drugs
  • Intrathecal Drug Administration
  • Intracavernosal Injection

Physicochemical Drug Interactions and Incompatibilities

  • pH Effects in Vitro and in Vivo
  • Dilution of Mixed Solvent Systems
  • Cation-Anion Interactions
  • Polyions and Drug Solutions
  • Chelation and Other Forms of Complexation
  • Other Complexes
  • Adsorption of Drugs
  • Drug Interactions with Plastics
  • Protein Binding

Peptides, Proteins and Other Biopharmaceuticals

  • Structure and Solution Properties of Peptides and Proteins
  • The Stability of Proteins and Peptides
  • Protein Formulation and Delivery
  • A Therapeutic Protein and a Peptide
  • DNA and Oligonucleotides
  • Therapeutic Monoclonal Antibodies

In Vitro Assessment of Dosage Forms

  • Dissolution Testing of Solid Dosage Forms
  • In Vitro-in Vivo Correlations
  • In Vitro Evaluation of Nonoral Systems
  • Rheological Characteristics of Products
  • Adhesivity of Dosage Forms
  • Analysis of Particle Size Distribution in Aerosols


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Physicochemical Principles of Pharmacy
Fourth Edition
by Alexander T. Florence

2006 492 pages $64.00 + shipping
Texas residents please add 6.75 % sales tax

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