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Drug Development Book from C.H.I.P.S.

Principles of CNS Drug Development
From Test Tube to Patient
by John Kelly

Principles of CNS Drug Development outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in preclinical (using in vitro and in vivo models) and clinical experimentation to identifying future drug targets.

Containing up-to-date experimental evidence and detailing the main impediments in the pipeline of CNS drug discovery and development, this is a key reference for those involved in all stages of CNS drug discovery.

Key Features:

  • Discusses in detail the key stages of CNS drug discovery, outlining the particular requirements and obstacles for CNS drugs
  • Addresses safety concerns and future drug targets
  • Provides succinct background information about the major CNS diseases
  • Examples of specific drugs are used throughout to describe the development of a new drug from conception to clinical use and post-market surveillance
  • Primary reasons for drug failure are given for each stage

Contents

  1. Introduction
  2. An overview of the major CNS disorders
  3. Neurobiological substrates of CNS disorders
  4. Current pharmacological targets
  5. Premarketing efficacy evaluation
  6. Pharmacokinetic considerations: Absorption, distribution, metabolism and elimination
  7. Safety concerns
  8. Preclinical and clinical safety evaluation
  9. CNS drug targets in development and future perspectives

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Principles of CNS Drug Development
From Test Tube to Patient
by John Kelly

2010 • 324 pages • $148.95 + shipping
Texas residents please add 6.75 % sales tax

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