Chemical Biology Techniques and Applications
by Hiroyuki Osada
Protein Targeting with Small Molecules takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development.
Protein Targeting with Small Molecules examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides.
- Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins
- Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes
- Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors
- Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting
- Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules
- Chemical biology based on the small molecule-protein interaction
- Target Profiling of Small Molecules
- Novel application of affinity beads
- Immolization of small molecules on solid phase
- Application of phage display technique to identify the target protein
- Development of fluorescent probes for small molecules .
- Development of small molecule ligands and inhibitors
- Interaction of biological response modifier with proteins
- Chemical biology of cell motility inhibitors
- Chemical biology of cell surface oligosaccarides
- Chemical genomics based on yeast genetics
- Data Fact of small molecules and their target proteins