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Protein book from C.H.I.P.S.

Protein Degradation
Ubiquitin and the Chemistry of Life
edited by
R. J. Mayer
A. Ciechanover
and M. Rechsteiner

Protein Degradation lays the foundations of targeted protein breakdown via the ubiquitin pathway.

Protein Degradation compiles information on the initial steps of the ubiquitin pathway.

Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail.

All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes.

Protein Degradation is for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Contents:

  • Brief history of protein degradation and the ubiquitin system
  • N-terminal ubiquitination: Not such a rare modification anymore
  • Evolutionary origin of the activation step during ubiquitin dependent protein degration
  • RING fingers and relatives: determination of protein fate
  • Ubiquitin conjugation enzymes
  • The SCF ubiquitin E3 ligase
  • Structural biology of ubiquitin-protein ligases
  • The deubiquitinating enzymes
  • The 26S proteasome
  • Molecular machines for protein degradation
  • Proteasome regulator, PA700
  • Bioinformatics of ubiquitin domains and their binding partners
  • The COP9 signalosome: Its possible role in the ubiquitin system
Index

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Protein Degradation
Ubiquitin and the Chemistry of Life
edited by R. J. Mayer, A. Ciechanover, and M. Rechsteiner

2005 377 pages $229.00 + shipping
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