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Immunology book from C.H.I.P.S.

Therapeutic Monoclonal Antibodies
From Bench to Clinic
edited by Zhiqiang An

Therapeutic Monoclonal Antibodies is the first book that draws together all of the latest findings, tools, and practices that span the entire process of discovery, development, and clinical application of therapeutic monoclonal antibodies.

Coverage includes:

  • Basic antibody biology and antibody sources
  • Antibody engineering
  • Physiology and in vivo biology
  • Antibody production and delivery
  • Antibody therapeutic targets
  • Therapeutic monoclonal antibodies in clinical use and in clinal trial
  • Biogenerics/biosimilars

Contents

Part I: Antibody Basics

  1. Therapeutic Monoclonal Antibodies: Past, Present, and Future
  2. Antibody Molecular Structure
  3. Glycosylation of Therapeutic IgGs
  4. Antibody Databases and Tools: The IMGTw Experience

Part II: Antibody Sources

  1. Human Antibodies from Transgenic Mice
  2. Rabbit Hybridoma
  3. Human Antibody Repertoire Libraries

Part III: In Vitro Display Technology

  1. Antibody Phage Display
  2. Yeast Surface Display
  3. Ribosomal Display
  4. Bacterial Display of Antibodies
  5. Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells

Part IV: Antibody Engineering

  1. Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques
  2. Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor
  3. Engineering the Antibody Fc Region for Optimal Effector Function

Part V: Physiology and In Vivo Biology

  1. Antibody-Complement Interaction
  2. Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications
  3. Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies
  4. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
  5. Biodistribution and Imaging
  6. Antibodies and the Blood-Brain Barrier

Part VI: Antibody characterization

  1. Determination of Equilibrium Dissociation Constants
  2. Molecular and Functional Characterization of Monoclonal Antibodies
  3. Characterization of Heterogeneity in Monoclonal Antibody Products

Part VII: Antibody Expression

  1. Antibody Expression in Mammalian Cells
  2. Production of Antibodies in Pichia pastoris
  3. Production of Antibody Fab1 Fragments in E. coli
  4. Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs
  5. Production of Antibodies in Plants

Part VIII: Therapeutic Antibodies

  1. The Formulation and Delivery of Monoclonal Antibodies
  2. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates
  3. Follow-On Protein Products: What, Where, When, How
  4. Monomeric Fc Fusion Molecules
  5. Radioimmunotherapy: Current Status and Future Directions
  6. Antibody-Drug Conjugate Therapy

Abbreviations
Index

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Therapeutic Monoclonal Antibodies
From Bench to Clinic
edited by Zhiqiang An

2009 889 pages $169.95 + shipping
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