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Environmental Safety Book from C.H.I.P.S.

Uncertainty Modeling in Dose Response
Bench Testing Environmental Toxicity
edited by Roger M. Cooke

Uncertainty Modeling in Dose Response analyzes four active substances that were vetted with the US EPA as representative of current problems.

Leading contributors from the toxicology and risk assessment communities were invited to apply their methods to quantify model uncertainty in dose response for each case. The results they provided are very revealing of the properties, strengths, and weaknesses of the various approaches.

The data sets in Uncertainty Modeling in Dose Response are real and are proposed by the EPA as representative and relevant. In fact, each are so relevant that their names must be suppressed as each has a simple "uncertainty issue".

Difficult extrapolations are avoided. The subsequent analysis is hopefully rather straightforward, and the ultimate goal is to get the different methods known and available for further evaluation and discussion.

Contents

  1. Analysis of Dose-Response Uncertainty using Benchmark Dose Modeling
  2. Uncertainty Quantification for Dose-Response Models Using Probabilistic Inversion with Isotonic Regression: Bench Test Results
  3. Uncertainty Modeling in Dose Response Using Non-Parametric Bayes: Bench Test Results
  4. Quantifying Dose-Response Uncertainty Using Bayesian Model Averaging
  5. Combining Risks from Several Tumors using Markov Chain Monte Carlo
  6. Uncertainty in Dose Response from the Perspective of Microbial Risk
Index

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Uncertainty Modeling in Dose Response
Bench Testing Environmental Toxicity
edited by Roger M. Cooke

2009 230 pages $99.95 + shipping
Texas residents please add 6.75 % sales tax

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