ABC Transporters and Multidrug Resistance provides comprehensive coverage of the most current scientific research on ABC transporters and multidrug resistance.

ABC Transporters and Multidrug Resistance is an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.

Features of this book include:

• provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein
• explores the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms
• explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action
• offers essential information on the biological and clinical aspect of multidrug resistance

Contents

Part I: ABC Proteins: An Overview and Description of the Structure, Genome, Normal Tissue Expression, Physiological Aspect, and Mechanism of Action

1. The P-glycoprotein 170: Just a multidrug resistance protein or a protean molecule
2. Multidrug resistance-associated protein (MRP/ABCC proteins)
3. ABCG2: A new challenge in cancer drug resistance

Part II: ABC Proteins and Oncology: Expression, Detection, and Implication of AABC Proteins in Hematological Malignancies and Solid Tumors

4. Expression, detection, and implication of ABC proteins in acute myeloblastic leukemia
5. ABC proteins and oncology: Expression, detection, and implication of ABC proteins in solid tumors

Part III: ABC Proteins and Pathogenic Microorganisms

6. ABC transporters and resistance to antibiotics
7. ABC proteins involved in protozoan parasite resistance

Part IV: Multidrug Resistance (MDR) Modulation Through Inhibition of ABC Transporters: Design of Inhibitors and Mechanism of Action

8. Reversal agents for P-glycoprotein-mediated multidrug resistance
9. Reversal agents of multidrug resistance mediated by multidrug resistance-associated proteins (MRPs)
10. Reversal agents for breast cancer resistance protein (BCRP)-mediated multidrug resistance
11. Strategies to overcome drug resistance in acute and chronic leukemias
12. Multidrug resistance reversal in solid tumors

Part V: Biological and Clinical Aspects of Multidrug Resistance: The Role of the Transporters at the Main Protection Barriers (ABCB1, ABCC1, ABCC2, ABCG2) on the Bioavailability of Many Types of Drugs and Medications

13. ABC superfamily transporters at the human blood–brain barrier
14. The role of ABC transporters at the intestinal barrier
15. Genetic polymorphisms in ABC transporters

Index

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