Aneurysm Book from C.H.I.P.S.

The Abdominal Aortic Aneurysm
Genetics, Pathophysiology, and Molecular Biology
edited by M. David Tilson

The Abdominal Aortic Aneursym integrates new insights into the etiology and pathology of aneurismal disease, including physiologic and genetic causes.

The Abdominal Aortic Aneurysm:

  • assess the benefits of risk of rupture assessment at different ages and thresholds of abdominal aortic aneurysm in the context of epidemiologic studies
  • examine the use of animal models in the study of abdominal aortic aneurysm and its underlying pathobiology
  • integrate data on susceptibility and genetic causes of abdominal aortic aneurysms

The Abdominal Aortic Aneursym covers the biological aspects of the endovascular devices used to repair abdominal aortic aneurysm and the molecular biology and immunology in abdominal aortic aneurysm are included.


Epidemiology and Initiatives to Prevent Death from Rupture

  1. Epidemiology of Aortic Aneurysm Repair in the United States from 1993 to 2003
  2. A Biomechanics-Based Rupture Potential Index for Abdominal Aortic Aneurysm Risk Assessment: Demonstrative Application
  3. Long-term Relationship of Wall Stress to the Natural History of AAAs (Finite Element Analysis and Other Methods)
  4. A Summary of the Contributions of the VA Cooperative Studies on Abdominal Aortic Aneurysms
  5. Pharmacological Approaches to Prevent AAA Enlargement and Rupture
  6. Should Usual Criteria for Intervention in Abdominal Aortic Aneurysms be “Downsized” Considering Reported Risk-Reduction With Endovascular Repair?

Animal Models

  1. Pathophysiology of Abdominal Aortic Aneurysms:Insights from the Elastase-Induced Model in Mice with Different Genetic Backgrounds
  2. Regression of Abdominal Aortic Aneurysm by Inhibition of c-Jun N-Terminal Kinase in Mice
  3. Role of the Renin-Angiotensin System in the Development of Abdominal Aortic Aneurysms in Animals and Humans
  4. AAA Disease: Mechanism, Stratification and Treatment
  5. Refinements in Mathematical Models to Predict Aneurysm Growth and Rupture

Enzymology - Another Approach to Interventional Pharmacology

  1. AAA – A complex Multifactorial Disease: Interactions of Polymorphisms of Inflammatory Genes, Features of Autoimmunity, and Current Status of MMPs
  2. The Intraluminal Thrombus as a Source of Proteolytic Activity
  3. Activators of Plasminogen and the Progression of Small Abdominal Aortic Aneurysms
  4. Is There a Role for Macrophage 5-Lipoxygenase Pathway in Aortic Aneurysm Development in Apolipoprotein E Deficient Mice?
  5. Do Cathepsins Play a Role in AAA Pathogenesis?
  6. MMP-2: The Forgotten Enzyme in Aneurysm Pathogenesis

Biological Aspects of Endovascular Devices to Repair AAA

  1. Current Status of Endovascular Repair of Infrarenal Abdominal Aortic Aneurysms in the Context of 50 Years of Conventional Repair
  2. Animal Models of Endovascular AAA Repair
  3. Aortic Aneurysm, Thoracoabdominal Aneurysm, Juxtarenal Aneurysm, Fenestrated Endografts, Branched Endografts, Endovascular Aneurysm Repair
  4. Vibrometry: A Novel Non-invasive Application of Ultrasonographic Physics to Estimate\Wall Stress in Native Aneurysms
  5. Combining Open and Endovascular Approaches to Complex Aneurysms
  6. Engineering Improvements in Endovascular Devices: Design and Validation

Genetics and Immunology in AAA

  1. The Abdominal Aortic Aneurysm (AAA) is a Specific Antigen-driven T-cell Disease
  2. Genes predisposing to rapid aneurysm growth
  3. Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Potential Relevance to. Abdominal Aortic Aneurysms
  4. Structural and Functional Genetic Disorders of the Great Vessels and Outflow Tracts
  5. Genome-wide approach to finding AAA susceptibility genes in humansa
  6. The Candidate Gene Approach to Susceptibility for Abdominal Aortic Aneurysm (AAA): TIMP1, HLA-DR-15, Ferritin Light Chain, and Collagen XI-ALPHA-1

Short Papers

Chapters 30-49


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The Abdominal Aortic Aneurysm
Genetics, Pathophysiology, and Molecular Biology
edited by M. David Tilson

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