A Practical Guide
edited by Katya Tsaioun
ADMET for Medicinal Chemists provides medicinal chemists insights into the field of early ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicology), giving them a how-to for implementing early ADMET testing in their workflows, and maximizing the success of drug candidates in preclinical and clinical studies.
Covers all key areas of the drug development process, including:
- Technical considerations when wselecting reclinical drug candidates
- Guidelines for how to avoid pitfalls during drug design and discovery
- Proven cutting-edge approaches to preclinical studies and drug design
- Essential computer methods for designing molecules with desired properties
- Absorption and physicochemical properties of New Chemical Entities (NCE)
- The concepts underlying pharmacokinetics
- Assays for testing cardiac safety, genetic toxicity, and hepatic toxicity
- In vivo toxicological considerations and complying with FDA requirements
Contents
- Introduction
- In Silico ADME/Tox Predictions
- Absorption and Physicochemical Properties of the NCE
- ADME
- Pharmacokinetics for Medicinal Chemists
- Cardiac Toxicity
- Genetic Toxicity: In Vitro Approaches for Medicinal Chemists
- Hepatic Toxicity
- In Vivo Toxicological Considerations
- Preclinical Candidate Nomination and Development
- Fragment-Based Drug Design: Considerations for Good ADME Properties
Index
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