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Advances in Nueurology
Volume 99

Tourette Syndrome
by John T. Walkup

Advances in Neurology Volume 99 provides a summary review of all recently published and ongoing research initiatives related to Tourette Syndrome.

The latest research is presented in a clinical context, and controversial issues are fully discussed using an evidence-based approach.

These issues include the following:

  • The prevalence of Tourette Syndrome
  • The nature of the Tourette Syndrome phenotype
  • The role of autoimmunity in the development of Tourette Syndrome
  • The role of comorbidity in functional outcomes of Tourette Syndrome patients
  • Approaches to identifying the Tourette Syndrome gene/genes


Clinical Phenomenology

  • Phenomenology and Natural History of Tic Disorders

Co-Morbid Disorders

  • Attention Deficit Hyperactivity Disorder: The Childhood Co-Morbidity That Most Influences the Disability Burden in Tourette Syndrome
  • Obsessive-Compulsive Disorder in Tourette Syndrome
  • Behavioral and Affective Disorders in Tourette Syndrome
  • Tics Associated with Other Disorders

New Findings in Basic Neurosciences

  • Preclinical Models Relevant to Tourette Syndrome
  • Neurobiology of Basal Ganglia and Tourette Syndrome: Basal Ganglia Circuits and Thalamocortical Outputs
  • Neurobiology of Basal Ganglia and Tourette Syndrome: Striatal and Dopamine Function

Neuroimaging and Neurophysiology

  • Motor Cortex Inhibitory Function in Tourette Syndrome, Attention Deficit Disorder, and Obsessive Compulsive Disorder: Studies Using Transcranial Magnetic Stimulation
  • Functional Neuroimaging of Tourette Syndrome: Advances and Future Directions

Genetics and Molecular Biology of TS

  • A Genome-Wide Scan and Fine Mapping in Tourette Syndrome Families
  • Web-Based Consensus Diagnosis for Genetics Studies of Gilles de la Tourette Syndrome
  • Genes and Tourette Syndrome: Scientific, Ethical, and Social Implications

Immunology and TS

  • Preclinical/Clinical Evidence of Central Nervous System Infectious Etiology in PANDAS
  • PANDAS: Overview of the Hypothesis
  • Autoimmunity and Pediatric Movement Disorders
  • PANDAS: To Treat or Not to Treat?

Epidemiology and Defining the Phenotype

  • Disruptive Behavior Problems in a Community Sample of Children with Tic Disorders

Advances in Treatment

  • Treatment of Tics
  • Attention Deficit Hyperactivity Disorder, Chronic Tic Disorder, and Methylphenidate
  • Treatment of Co-Morbid Obsessive Compulsive Disorder, Mood, and Anxiety Disorders
  • Treatment of Aggression in Tourette Syndrome
  • Behavioral Treatments for Tic Suppression: Habit Reversal Training
  • Behavior Therapy: Other Interventions for Tic Disorders
  • Behavioral Neurosurgery
  • Future and Alternative Therapies in Tourette Syndrome


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Advances in Neurology
Volume 99

Tourette Syndrome
by John T. Walkup

2006 267 pages $174.00 + shipping
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