Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics
edited by Reinhard Neubert
and Hans-Hermann Rüttinger

This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds—offering strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate developments in controlled drug delivery and targeting.

Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics contains current applications and procedures to:

• identify binding constants between drugs, biological structures, proteins, nucleic acids, and plasmids
• increase drug bioavailability
• enhance the permeability, solubility, strength, and function of drug formulations
• examine protein-protein exchanges and reactions
• calculate pKa values

Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics is an excellent guide for biochemical, pharmaceutical, analytical, and medicinal chemists; biochemists; molecular and cell biologists; and upper-level undergraduate and graduate students in these disciplines.

Contents

1. Chemometric Analysis of Comprehensive Two-Dimensional Separations
2. Column Technology for Capillary Electrochromatography
3. Gas Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection (GC-ICP MS)
4. GC-MS Analysis of Halocarbons in the Environment
5. Microfluidics for Ultrasmall-Volume Biological Analysis
6. Recent Trends in Proteome Analysis
7. Improving Our Understanding of Reversed-Phase Separations for the 21st Century
8. Clinical Applications of High-Performance Affinity Chromatography

Index

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