This book discusses the role of the Aldo-Keto Reductase (AKR) superfamily in the metabolism of endogenous and exogenous toxicants. Like cytochrome P450s (CYPs), these enzymes play a central role in natural products, drugs, xenobiotics, and carcinogen metabolism.

Contents

1. General Overview
   1. Introduction and Overview of the Aldo-Keto Reductase Superfamily

2. Aldo-Keto Reductases and Endogenous Toxicants
   2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes Associated with Diabetic Complications
   3. Aldose Reductase Detoxifies Lipid Aldehydes and Their Gluthathione Conjugates
   4. Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids

3. Aldo-Keto Reductases and Exogenous Toxicants: Tobacco-Related Carcinogens
   5. Competing Roles of Reductases in the Detoxification of the Tobacco-Specific Nitrosamine Ketone NNK
   6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons
   7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from the Mouse
   8. Efficient Syntheses of the Active Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons
   9. Chemistry of Polycyclic Aromatic Hydrocarbons (PAH) o-Quinones Generated by the Aldo-Keto Reductase Pathway of PAH Activation
   10. Analysis of Etheno 2'-Deoxyguanosine Adducts as Dosimeters of Aldo-Keto Reductase Mediated-Oxidative Stress

4. Aldo-Keto Reductases and Exogenous Toxicants: Mycotoxins, Aldehydes, and Ketones
   11. Aflatoxin Aldehyde Reductases
   12. Competing Reactions of Aflatoxin B1 Dialdehyde: Enzymatic Reduction versus Adduction with Lysine
   13. The Use of Mammalian Cell Lines to Investigate the Role of Aldo-Keto Reductases in the Detoxification of Aldehydes and Ketones

5. Aldo-Keto Reductases, the Stress Response, and Cell Signaling
   14. Aldose Reductase and the Stress Response
   15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory Signals
   16. Aldo-Keto Reductases in the Stress Response of the Budding Yeast Saccharomyces cerevisiae

Index

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