Allosteric Receptor Modulation in Drug Targeting covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems.

Features:

• Provides a thorough analysis of the impact of allosterism on drug action
• Includes a section on mathematical models of allosteric receptor interactions for predicting dose-response behavior
• Vontains detailed examples of allosterism in relation to a variety of receptor systems
• Describes comparative features on the given examples of receptors

Contents

Basic Principles

• Allosteric Modulation of Receptor Function
• Characteristics of Allosterism in Drug Action
• Predicting Dose-Response Curve Behavior: Mathematical Models of Allosteric Ligand-Receptor Interactions

Ionotropic Receptors

• Allosteric Modulation of GABAA Receptors: A Pharmacology of Sleep, Anxiety and Memory
• Allosteric Interactions at the NMDA Receptor Channel Complex
• 5-HT3 Receptors
• Nicotinic Receptors

G-Protein Coupled Receptors

• Allosteric Modulation of G protein-coupled Receptors
• Adenosine Receptor
• Allosteric Modulators of Group III Metabotropic Glutamate Receptors as Novel Therapeutics
• Allosteric Modulation of Gamma-Aminobutyric Acid B (GABAB) Receptors
• Allosteric Interactions at GABAB and Related G-Protein-Coupled Receptors
• Muscarinic Receptors: Targeting Allosteric Modulation by the Development and Application of the Radiolabeled Allosteric Agent [3H]dimethyl-W84
• Alpha 2 Adrenoceptors: Physiology, Pharmacology and Allosteric Modulation

Index

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