Aminoglycoside Antibiotics is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design.

Aminoglycoside Antibiotics is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals.

Contents

1. In the Beginning There was Streptomycin
2. The Biochemistry and Genetics of Aminoglycoside Producers
3. Mechanisms of Aminoglycoside Antibiotic Resistance
4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics
5. NMR Structural Studies of Aminoglycoside: RNA Interaction
6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding A Sites Free and Complexed with Aminoglycosides
7. Binding of Anitbiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome
8. Metalloaminoglycosides: Chemistry and Biological Relevance
9. Adverse Effects of Aminoglycoside Therapy
10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives
11. Novel Targets for Aminoglycosides

Index

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