Amyotrophic Lateral Sclerosis covers all the essential information clinicians require for daily practice, as well as providing a reader-friendly approach to every aspect of ALS.

Features:

• Stands at the forefront of ALS neurobiology and research-addressing topics such as protein aggregation, excitotoxicity, apoptosis, genetic influence, and inflammation
• Addresses translational research and high-throughput drug development
• Discusses methods and techniques to maximize the quality of patient care and treatment
• Fully details intensive pharmacotherapy for symptomatic management, as well as pharmacotherapy in clinical trials
• Illustrates patient evaluation, diagnosis, and therapy, and outlines alternative treatment options
• Assesses the strengths and limitations of individual ALS multidisciplinary team clinics approaches
• Covers key issues in nutritional, respiratory, and end-of-life care
• Reviews the history and epidemiology of the disease

Contents

• Overview of Clinical ALS
• History
• Epidemiology
• Pathology
• Clinical Features: Motor System
• Clinical Features: Dementia and Cognitive Deficits
• Familial ALS and Genetic Approaches to ALS
• Electrophysiology and Other Objective Markers
• Classification, Diagnosis and Presentation of Diagnosis of ALS
• Natural History
• Translational Research in ALS: Mechanisms behind therapy
• Motor Neuron: The origin, definition and function
• Neurodegeneration
• Excitotoxicity
• Oxidative Stress. Neuroinflammation
• Apoptosis
• Cytoskeleton
• Mitochondria
• Environmental Neurotoxicity
• Genetic Causes and Predisposition
• Protein Aggregate Disease
• Proteiomic and Metabolomic Approach
• Infections and Autoimmunity
• Gene Transfer Technology
• High Through-put Technology
• Animal Models
• Restoration-Practical Approach
• Clinical Trial Methodology
• ALS Therapy: Care and Management
• Multidisciplinary Approach: Ideal Care Centers and World Perspective
• Impact of National ALS Care Database and Practice Parameters
• Symptomatic Pharmacotherapy: Bulbar and Constitutional Symptoms
• Pharmacotherapy: In clinical trials
• Physical Rehabilitation
• Speech Therapy and Augmentative Communication/Assistive Technology
• Nutritional treatment: Theoretical and Practical issues
• Respiratory care: Basic and Practical
• Psychosocial care: Patient and Caregiver Support
• Palliative Care
• Palliative Care: Family Perspective
• Decision Making for End of Life
• National ALS Study Group: Future of ALS Clinical Research

Index

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