Anaesthesia Science presents the scientific foundations upon which the clinical practice of anaesthesia and care of the critically ill are based.

Anaesthesia Science begins with contemporary techniques for evaluation of the macula, including:

• Written on the basis that basic science underlies the practice of anaesthesia
• Contributors include some of the world’s most eminent anaesthesiologists
• Provides coverage on less well appreciated aspects of the subject, such as the microcirculation, multi-organ failure, and the theory of pain
• Thoroughly integrates the clinical practice of anaesthesia with basic sciences, providing all the information needed in one convenient source
• Based on the Fellowship of the Royal College of Anaesthetists (FRCA) syllabus and aimed at trainee anaesthetists preparing for the FRCA, the European Diploma of Anaesthesiology and other equivalent examinations

Contents

1. Pharmacokinetic principles
2. Pharmacodynamics
3. Pharmacogenomics
4. Receptors and second messenger systems
5. Anaphylaxis
6. Refl ections on chirality
7. Ion channels
8. Immunosuppression
9. Mechanisms of anaesthesia: a role for voltage-gated K channels?
10. Use and abuse of antibiotics

Physiology

11. Infl ammation and immunity
12. Shock: pathogenesis and pathophysiology
13. Cellular physiology
14. Acid–base balance: albumin and strong ions
15. Fluids and electrolytes
16. The microcirculation
17. Respiratory physiology at the molecular level
18. Non-respiratory functions of the lung
19. The brain as a site of infl ammation after acute injury
20. Heart failure
21. The hormonal and metabolic response to anaesthesia, surgery and trauma
22. Temperature regulation
23. Theories of pain
24. Neuromuscular transmission and function

Clinical measurement

25. Magnetic resonance imaging
26. Nanotechnology
27. Assessment of the cardiovascular system
28. Assessment of respiratory function
29. Monitoring the depth of anaesthesia
30. Research study design

Index

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