Analgesia attempts to summarize the current state of knowledge on mechanisms underlying the various effects of analgesics, their side effect profiles, and their indications and contraindications in clinical use.

Analgesia also gives insights into current efforts to discover novel mechanisms underlying the generation of different types of pain and the resulting development of new modulating compounds.

Contents

• Peripheral and Central Mechanisms of Pain Generation

Drugs in Clinical Use

• Opioids
• Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones
• Local Anesthetics
• Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headaches
• Anti-convulsants and Anti-depressants

Compounds in Preclinical Development

• Neuropeptide and Kinin Antagonists
• Glutamate Receptor Ligands
• Adrenergic and Cholinergic Compounds
• Cannabinoids and Pain

Future Targets in Analgesia Research

• Adenosine and ATP Receptors
• Ion Channels in Analgesia Research
• Protein Kinases as Potential Targets for the Treatment of Pathological Pain

Pain Management Beyond Pharmacotherapy

• Placebo and Endogenous Mechanisms of Analgesia
• Limitations of Pharmacotherapy: Behavioral Approaches to Chronic Pain

Index

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