edited by Janos Fischer
Analogue-Based Drug Discovery is an authoritative and systematic overview of past and current strategies for successful drug development by modification spans all important drug classes and all major therapeutic fields.
- Discusses analog-based drug discovery for, among others, beta-blockers, ACE inhibitors, steroids, opiates, coxibs, stigmines, proton pump inhibitors, platinum compounds and quinolones
- Includes case studies on selected commercially successful drug analogs provide prime advice for new drug development projects based on modification
- Details an exclusive table of the 1,000 most successful drug analogs according to IMS ranking, classified in terms of chemical structure, mode of action and patentability
General Aspects of Analogue-Based Drug Discovery
- Analogues as a Means of Discovering New Drugs.
- Drug Likeness and Analogue-Based Drug Discovery.
- Privileged Structures and Analog-Based Drug Discovery
Selected Examples from the Analogue-Based Drug Discoveries
- Development of Anti-Ulcer H2-Receptor Histamine Antagonists.
- Esomeprazole in the Framework of Proton-Pump Inhibitor Development.
- The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole.
- Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors.
- Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers.
- Optimizing Antihypertensive Therapy by Angiotensin-Converting Enzyme Inhibitors.
- Case Study of Lacidipine in the Research of New Calcium Antagonists.
- Selective Beta-Adrenergic Receptor-Blocking Agents.
- Case Study: "Esmolol Stat".
- Development of Organic Nitrates for Coronary Heart Disease.
- Development of Opioid Receptor Ligands.
- Structural Analogues of Clozapine.
- Quinolone Antibiotics: The Development of Moxifloxacin.
- The Development of Bisphosphonates as Drugs.
- Cisplatin and its Analogs for Cancer Chemotherapy.
- The History of Drospirenone.
- Histamine H1 Blockers: From Relative Failures to Blockbusters Within Series of Analogues.
- Corticosteroids: From Natural Products to Useful Analogues
Table of Selected Analogue Classes