Analytical and Practical Aspects of Drug Testing in Hair provides practical coverage of the best drug testing techniques and examines the drugs themselves.

Features:

• Summarizes the numerous clinical, forensic, workplace, and doping applications of hair analysis
• Discusses current sensitive analytical techniques that enable the analysis of drugs in unconventional biological specimens
• Resolves medical questions through discussions of technological applications
• Presents a variety of mass spectrometric (MS) procedures
• Supplies ways to detect drug and alcohol abuse through hair analysis
• Offers a collection of diverse international opinions from contributors who are authorities in their respective fields

Contents

Drug Incorporation into Hair

• Hair Physiology
• Drug Incorporation Routes
• Mechanisms of Binding

Passive Exposure, Decontamination Procedures, Cutoffs, and Bias

• Historical Concerns for Passive Exposure in Hair Analysis
• Mechanisms for Incorporation of Drugs into Hair
• Drugs in the Environment
• Decontamination Procedures
• Cutoffs and Why They Matter
• Bias in Hair Testing

Opioids Testing in Hair

• Opiates

Hair Analysis for Cocaine

• Analytical Methodologies
• Quality Control
• Interpretation of Results

Determination of Cannabinoids in Human Hair

• Metabolism, Incorporation of Cannabinoids into Hair
• Analytical Techniques for the Detection of Cannabinoids Decontamination Processes
• Issues to Be Considered
• Criteria for Obtaining a Cannabis-Positive Hair-Test Result
• Controlled Studies: Empirical Data Analysis of a Large Sample of
• Hair Specimens
• Reported Concentrations of Cannabinoids in Hair

Amphetamine Determination in Hair

• Amphetamine Determination

Pharmaceuticals in Hair

Screening Strategies in Hair Analysis on Drugs

• Immunochemical Screening in Hair Analysis
• Screening and Confirmation by GC-MS/MS
• Multianalyte Screening Using LC-MS/MS
• Crime Cases Solved by Screening Hair Using LC-MS/MS

Clinical Applications of Hair Analysis

• Hair Analysis in Psychiatric Patients
• Hair Analysis in Epileptic Management
• Hair Analysis as Evidence of Prenatal and Postnatal Exposure to
• Drugs and Tobacco
• Hair Nicotine as a Marker of Active and Passive Exposure to Tobacco
• Drug Addiction and Opiate-Maintenance Programs
• Therapeutic Drug Monitoring

Hair in Postmortem Toxicology

• Methodological Aspects
• Strategies in Postmortem Work

Detection of Doping Agents in Human Hair

• Detection of Doping Agents

Applications of Hair in Drug-Facilitated Crime Evidence

• Analytical Strategy

Application of Hair in Driving-License Regranting

• Sensitivity of Drug Abuse Detection: Comparison between
• Urine and Hair Analysis
• Hair Sampling for Drug Analysis
• Manipulation of Drug Concentrations in Hair
• Hair Analysis for Regranting Driver's License
• Regulations in Other Countries

Alcohol Markers in Hair

• General Problems in Detection of Chronic Alcohol Abuse
• Fatty Acid Ethyl Esters (FAEE)
• Ethylglucuronide (EtG)
• Combined Use of FAEE and EtG
• Benzoylecgonine Ethyl Ester (Cocaethylene, BE-Et)

Workplace Drug Testing Using Hair Samples

• Sample Collection
• Screening Procedures
• Sample Preparation: Washing and Extraction Methods
• Confirmation by Mass Spectrometry
• Testing Body Hair Samples in Workplace Testing

Metals

• Hair Metal Incorporation
• Hair Washing Procedure and Sample Preparation
• Hair Elements Analytical Methods
• Metal Hair Reference Values
• Hair Metal Analysis Interpretation
• Hair Metal Analysis Results
• Metal Hair Certified Reference Material

Index

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