A comprehensive review of the current status of antidepressants - how we arrived at this point in their evolution and where we are going in both the near and the long term.

Antidepressants: Past, Present and Future employs both a scientific and historical approach to accomplish these goals. This volume is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that it provides a comprehensive and logical approach to this important group of medications. This book is being published as we mark the end of the first 50 years of the modern antidepressant era.

Antidepressants: Past, Present and Future is an ideal reference for scientists, researchers and clinicians in the fields of pharmacology and toxicology, neurology and psychiatry.

Contents

1. Basic Principles: Pharmacologic Science
   1. Biochemical and Physiological Processes in Brain Function and Drug Actions
   2. General Principles of Pharmacokinetics
   3. Therapeutic Drug Monitoring of Antidepressants

2. Basic Principles: Clinical Science
   4. Biological Markers of Depression
   5. Quality of Life and Rating Scales of Depression

3. Current Pharmacotherapy of Major Depressive Disorder
   6. Overview of Currently Available Antidepressants
   7. Tricyclic Antidepressants
   8. Monoamine Oxidase Inhibitors
   9. Selective Serotonin Reuptake Inhibitors
   10. Other Antidepressants

4. Use of Antidepressants in Special Populations
   11. Children and Adolescents
   12. Women
   13. Older Adults
   14. Bipolar Mood Disorders
   15. Treatment-Refractory Depression
   16. Personality Disorders

5. Future Directions in the Treatment of Major Depressive Disorder
   17. New Hypotheses to Guide Future Antidepressant Drug Development
   18. Promising New Directions in Antidepressant Development
   19. Role of Pharmacogenetics/Pharmacogenomics in the Development of New Antidepressants

Appendix
Subject Index

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