The thoroughly revised, updated Fifth Edition of this classic is the most comprehensive, current, and authoritative reference on all anticonvulsants available today.

Antiepileptic Drugs features detailed profiles of newer drugs--including levetiracetam, oxcarbazepine, tiagabine, topiramate, and zonisamide--and new chapters on use of antiepileptic drugs in children and during pregnancy.

Drugs are covered in alphabetical order and in an easy-to-follow format: mechanisms of action; chemistry, biotransformation, and pharmacokinetics; interactions; clinical efficacy and use; and adverse effects.

Coverage of clinical use includes nonepileptic and psychiatric disorders where appropriate. This edition has been trimmed to manageable size by shortening chapters on older, less frequently used drugs.

Contents

1. General Principles
   1. Principles of Antiepileptic Drug Action
   2. Neurophysiological Effects of Antiepileptic Drugs
   3. Discovery and Preclinical Development of Antiepileptic Drugs
   4. New Antiepileptic Drug Development: Medical Perspective
   5. Clinical Development of Antiepileptic Drugs: Industry Perspective
   6. The Development of Antiepilepsy Drugs: Regulatory Perspective
   7. Antiepileptic Drug Monotherapy in Adults: Selection and Use in New-Onset Epilepsy
   8. Combination Therapy and Drug Interactions
   9. Laboratory Monitoring of Antiepileptic Drugs
   10. Safety Monitoring of Antiepileptic Drugs
   11. Use of Antiepileptic Drugs in Children
   12. Antiepileptic Drug Use in Women
   13. Epilepsy in the Elderly
   14. Treatment of Status Epilepticus
   15. Prevention of Epileptogenesis

2. Benzodiazepines
   16. Mechanisms of Action
   17. Chemistry, Biotransformation, and Pharmacokinetics
   18. Clinical Efficacy and Use in Epilepsy
   19. Adverse Effects

3. Carbamazepine
   20. Mechanisms of Action
   21. Chemistry, Biotransformation, and Pharmacokinetics
   22. Interactions with Other Drugs
   23. Clinical Efficacy and Use in Epilepsy
   24. Clinical Efficacy and Use in Other Neurological Disorders
   25. Clinical Efficacy and Use in Psychiatric Disorders
   26. Adverse Effects

4. Felbamate
   27. Felbamate

5. Gabapentin
   28. Mechanisms of Action
   29. Chemistry, Biotransformation, Pharmacokinetics, and Interactions
   30. Clinical Use
   31. Clinical Efficacy and Use in Other Neurological Disorders
   32. Clinical Efficacy and Use in Psychiatric Disorders
   33. Adverse Effects

6. Lamotrigine
   34. Mechanisms of Action
   35. Chemistry, Biotransformation, and Pharmacokinetics
   36. Interactions with Other Drugs
   37. Clinical Efficacy and Use in Epilepsy
   38. Efficacy and Use in Nonepileptic Disorders
   39. Adverse Effects

7. Levetiracetam
   40. Mechanisms of Action
   41. Chemistry, Biotransformation, Pharmacokinetics, and Drug Interactions
   42. Clinical Use
   43. Adverse Experiences

8. Oxcarbazepine
   44. Mechanisms of Action
   45. Chemistry, Biotransformation, and Pharmacokinetics
   46. Interactions with Other Drugs
   47. Clinical Efficacy and Use in Epilepsy
   48. Clinical Efficacy and Use in Psychiatric Disorders
   49. Adverse Effects

9. Phenobarbital and Other Barbituates
   50. Mechanisms of Action
   51. Chemistry, Biotransformation, and Pharmacokinetics
   52. Interactions with Other Drugs
   53. Clinical Efficacy and Use in Epilepsy
   54. Clinical Efficacy and Use in Nonepileptic Disorders
   55. Adverse Effects
   56. Methylphenobarbital

10. Phenytoin and Other Hydantoins
    57. Mechanisms of Action
    58. Chemistry and Biotransformation
    59. Interactions with Other Drugs
    60. Clinical Efficacy and Use in Epilepsy
    61. Clinical Efficacy and Use in Other Neurological Disorders
    62. Clinical Efficacy and Use in Psychiatric Disorders
    63. Adverse Effects
    64. Fosphenytoin

11. Primidone
    65. Primidone

12. Succinimides
    66. Mechanisms of Action
    67. Ethosuximide: Chemistry, Biotransformation, Pharmacokinetics, and Drug Interactions
    68. Clinical Efficacy and Use in Epilepsy
    69. Adverse Effects
    70. Methsuximide

13. Tiagabine
    71. Mechanisms of Action
    72. Chemistry, Biotransformation, and Pharmacokinetics
    73. Drug Interactions
    74. Clinical Efficacy and Use in Epilepsy
    75. Clinical Efficacy and Use in Nonepileptic Disorders
    76. Adverse Effects

14. Topiramate
    77. Mechanisms of Action
    78. Chemistry, Biotransformation, and Pharmacokinetics
    79. Drug Interactions
    80. Clinical Efficacy and Use in Epilepsy
    81. Clinical Efficacy and Use in Nonepileptic Disorders
    82. Adverse Effects

15. Valproic Acid
    83. Mechanisms of Action
    84. Chemistry, Biotransformation, and Pharmacokinetics
    85. Drug Interactions
    86. Clinical Efficacy and Use in Epilepsy
    87. Clinical Efficacy and Use in Other Neurological Disorders
    88. Clinical Efficacy and Use in Psychiatric Disorders
    89. Adverse Effects

16. Vigabatrin
    90. Vigabatrin

17. Zonisamide
    91. Mechanisms of Action
    92. Chemistry, Biotransformation, and Pharmacokinetics
    93. Drug Interactions
    94. Clinical Efficacy and Use in Epilepsy
    95. Adverse Effects

18. Drugs in Development
    96. Pregabalin
    97. Rufinamide
    98. Drugs in Early Clinical Development

Subject Index

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