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Antigen Presenting Cells
From Mechanisms to Drug Development
edited by Harald Kropshofer

Antigen Presenting Cell highlights evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the immune system.


Antigen Presentation in the Immune System

  • Some Old and Some New Findings on Antigen Processing and Presentation
  • HEL Processing
  • Selection of Peptide Segments of HEL
  • HEL: Conformational Isomers
  • Negative Selection and Peripheral Activation to HEL Peptides
  • Response to HEL Immunization in the Draining Lymph Node

Molecular Mechanisms of Antigen Processing

  • Antigen Entry Routes – Where Foreign Invaders Meet Antigen Presenting Cells
  • Antigen Entry via the Gastrointestinal Tract
  • Antigen Entry via the Skin
  • Systemic Dissemination of Antigens/Infectious Microorganisms
  • Antigen Presenting Cells in the Liver

Antigen Processing in the Context of MHC Class I Molecules

  • Tracing the Needle in the Haystack: The Efficiency of Antigen Processing and Presentation by MHC Class I Molecules
  • The “Classical” Route: Loading of MHC Class I Molecules With Peptides Generated in the Cytoplasm
  • Crossing the Border – Peptide Translocation into the ER by TAP
  • Fitting in the Best: TAP-associated Peptide Loading Complex Optimizes MHC-I Peptide Binding
  • On the Way Out: MHC-I Antigen Processing along the Secretory Route
  • Closing the Circle – Cross-presentation of Endocytosed Antigens by MHC-I Molecules

Antigen Processing for MHC Class II

  • Types of Antigen Presenting Cells
  • Antigen Uptake by APCs
  • Generation of Antigenic Peptides
  • Assembly of MHC II Molecules
  • Export of MHC II and Organization on the Cell Surface
  • Viral and Bacterial Interference

Antigen Processing and Presentation by CD1 Family Proteins

  • CD1 Genes and Classification of CD1 Proteins
  • Structure and Biosynthesis of CD1 Proteins
  • Foreign Lipid Antigens Presented by Group 1 CD1
  • Self Lipid Antigens Presented by CD1
  • Group 2 CD1-restricted TC ells
  • Tissue Distribution of CD1 Proteins
  • Subcellular Distribution and Intracellular Trafficking of CD1
  • Antigen Uptake, Processing and Loading in the CD1 Pathway

Antigen Presenting Cells’ Ligands Recognized by T- and Toll-like Receptors

  • Naturally Processed Self-peptides of MHC Molecules
  • Milestone Events
  • Progress in Sequence Analysis of Natural Peptides
  • Natural Class II MHC-associated Peptides from Different Tissues and Cell-types
  • The CLIP Story
  • Outlook: Natural Peptides as Diagnostic or Therapeutic Tools

Target Cell Contributions to Cytotoxic T Cell Sensitivity

  • Intercellular Adhesion Molecule 1 (ICAM-1)
  • Major Histocompatability Complex (MHC)

Stimulation of Antigen Presenting Cells: from Classical Adjuvants to Toll-like Receptor (TLR) Ligands

  • Synopsis
  • Pathogen-associated Features that Drive Efficient Immune Responses
  • Composition and Function of Adjuvants
  • TLR Protein Family in Mammals
  • TLR Signaling
  • TLR-independent Recognition of PAMPs: Nods, PKR and Dectin-1
  • Therapeutic Potential of TLRs and their Ligands

The Repertoire of Antigen Presenting Cells

  • Evolution and Diversity of Macrophages
  • Evolution of Macrophages: Immunity without Antigen Presentation
  • Diversity of Macrophages in Mammalian Tissues

Macrophages – Balancing Tolerance and Immunity

  • Balancing Tolerance and Immunity
  • Ramifications of the Paradigm: Asthma
  • Ramifications of the Paradigm: Autoimmunity
  • Summary and Conclusions: Towards Immune System Modeling and Therapeutics

Polymorphonuclear Neutrophils as Antigen-presenting Cells

  • PMN as Antigen-presenting Cells.
  • Evolution of Newer Thoughts as PMN March to a Newer Horizon

Microglia – The Professional Antigen-presenting Cells of the CNS

  • Introduction: Microglia and CNS Immune Privilege
  • Do Microglia Differ from Other Macrophage Populations
  • To What Extent is Microglial Phenotype Determined by the CNS Microenvironment
  • Microglia versus Macrophages/Dendritic Cells as Professional Antigen-presenting Cells
  • TREM-2 Positive Microglia may Represent Subsets Predisposed to Differentiate into Effective Antigen-presenting Cells
  • Are Microglia the “Professional Antigen-presenting Cell of the CNS

Contribution of B Cells to Autoimmune Pathogenesis

  • Autoimmunity and Immune Deficiency
  • Disturbed Homeostasis of Peripheral B Cells in Autoimmune Diseases
  • Signal Transduction Pathways in B Cells
  • B Cell Abnormalities Leading to Rheumatoid Arthritis
  • Depleting anti-B Cell Therapy as a Novel Therapeutic Strategy

Dendritic Cells (DCs) in Immunity and Maintenance of Tolerance

  • Dendritic Family
  • DCs at Various Stages of Maturation
  • Immature DCs
  • Homing of DCs into Secondary Lymphoid Organs
  • DCs as Adjuvants
  • DC Subsets
  • DCs in TC ell Polarization
  • TolerogenicDC
  • Mechanisms of Tolerance
  • CD28-B7 Bidirectional Signaling
  • Crosspriming
  • Cross-presentation and Cross-tolerization
  • DC as Regulators of TC ell Recirculation
  • DC-based Immunotherapy of Cancer

Thymic Dendritic Cells

  • Thymic Dendritic Cells
  • Localisation and Isolation of Thymic DC
  • Pickup of Antigens by Thymic DC
  • Subtypes of Thymic DC
  • Major Thymic cDC Population
  • Minor Thymic cDC Population
  • Thymic pDC
  • Maturation State and Antigen Processing Capacity of Thymic DC
  • Cytokine Production by Thymic DC
  • DC of the Human Thymus
  • Turnover Rate and Lifespan of the Thymic DC
  • Endogenous versus Exogenous Sources of Thymic DC
  • Lineage Relationship and Differentiation Pathways of Thymic cDC
  • Lineage Relationships and Developmental Pathways of Thymic pDC
  • Thymic cDC do not Mediate Positive Selection
  • Thymic cDC and Negative Selection
  • Role of pDC in the Thymus

Antigen Presenting Cell-based Drug Development

  • Antigen Presenting Cells as Drug Targets
  • Roles of DC in disease
  • Marketed Drugs Affecting APC function
  • New Potential APC Drug Targets
  • APC per se as Drugs – DC-based Immunotherapy Therapy


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Antigen Presenting Cell
From Mechanisms to Drug Development
edited by Harald Kropshofer

2005 • 652 pages • $289.00 + shipping
Texas residents please add 6.75 % sales tax

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