Apoptosis and Cancer Therapy covers such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis.

Features:

• Analyzes apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects
• Focuses on recent developments in cancer therapy
• Aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries

Contents

Volume 1

Death Receptor

• The Role of CD95/CD95 Ligand Signaling in Apoptosis and Cancer
• The TRAIL Receptor-Ligand System: Biochemistry of Apoptosis Induction, Therapeutic Potential for Cancer Treatment and Physiological Function
• Mechanisms of Tumor Necrosis Factor-Induced Cell Death
• Cellular FLICE-inhibitory Protein: An Update
• Dependence Receptors and Apoptosis

Mitochondria

• Role of Mitochondrial Proteins in Apoptosis
• Omi/HtrA2: A Mitochondrial Serine Protease Regulating Cellular Life and Death
• Apoptosis-inducing Factor

Effector Systems

• Caspases: Agents of Defense and Destruction
• The Role of the Apoptosome in Apoptosis and Cancer Therapy

BCL-2 Family

• The Role of the Bcl-2 Protein Family in Tumorigenesis and Cancer Therapy
• Bax, Bak and Bid: Key Mediators of Apoptosis
• The BH3-only Proteins Puma and Noxa: Two Brothers in Arms

IAPs

• Inhibitor of Apoptosis Proteins
• Targeting the Survivin Pathway for Rational Cancer Therapy

Survival Pathways

• Nuclear Factor-kB in Apoptosis and Tumorigenesis
• Cell Survival Signaling through Phosphoinositide 3-kinase and Protein Kinase B
• Survival Regulation by Ras and Raf

Oncogenes/Tumor Suppressor Genes

• p53-mediated Apoptosis: A Multifaceted Story
• p73 Affects Cell Fate and Tumorigenesis
• RB and Cancer

Modulators

• Calcium Signaling in Apoptosis

Lysosomes and Nonapoptotic Pathways

• Lysosomes and Nonapoptotic Pathways

Phagotosis/Clearance

• The Role of "Eat Me", "Don't Eat Me" and "Find Me" Signals for the Efficient Removal of Apoptotic Cells
• Apoptotic Cell Clearance by Macrophages: Relevance to Tumor Pathogenesis

Volume 2

Model Systems

• Mouse Models in Cancer Research

Molecular Diagnosis

• Molecular Imaging in Cancer
• Microarray-based Expresson Profiling: From Technological Basics to Diagnostic Perspectives

Cellular Stress, DNA Damage and Repair

• Life and Death Decisions in Response to Stress
• Hypoxia in Cancer
• Apoptosis Induced by DNA-damaging Agents
• DNA Repair

Molecular Targets and Therapeutics

• Therapeutic Modulation of Apoptosis in Cancer Therapy
• Current Therapeutic Strategies Targetging Caspases in Disease
• Cancer Therapy by Reactivation of the p53 Apoptosis Pathway
• Small-molecule Inhibitors of the Apoptosis Proteins
• Inhibition of the Molecular Chaperone Heat Shock Protein 90 in Cancer: Consequences for the Regulation of Survival Signaling and Induction of Cell Death
• Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway
• Cermide Signaling in Apoptosis and Cancer Therapy
• Histone Deacetylase Inhibitors: Development as Anticancer Agents
• Exploiting Apoptosis Pathways for Glioblastoma Therapy
• Radiation Therapy and Apoptosis
• Tumor Angiogenesis

Index

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