Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases.

Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways.

Contents

1. Apoptotic Pathways and Their Regulation
2. Mechanisms of Anticancer Drug Action
3. Death Receptor Pathways as Targets for Anticancer Therapy
4. Caspases; Modulators of Apoptosis and Cytokine Maturation - Targets for Novel Therapies
5. The Intrinsic (Mitochondrial) Death Pathway and New Cancer Therapeutics: BCL-2 Family in Focus
6. Survivin, Other Laps, SMAC/DIABLO, and OMI/HTRA2 - Modulation of the Advancing Apoptotic Process
7. The Life Cycle of p53: A Key Target in Drug Development
8. Growth Factors, Receptors, and Kinases: Their Exploration to Target Cancer
9. Targets for Apoptotic Intervention in Rheumatoid Arthritis
10. Therapeutic Inhibition of Apoptosis Caused by Stroke
11. Monoclonal and Bispecific Antibodies as Novel Therapeutics
12. Targeting the Proteasome in Cancer Therapy
13. D-RNAi-Based Therapeutics
14. Nuclear Transcription Factor-kB: A Drug Target for all Seasons
15. Monitoring of Programmed Cell Death In Vivo and In Vitro, - New and Old Methods of Cancer Therapy Assessment
16. Current Strategies in Tumor-Targeting
17. Strategies of Protection of Normal Cells During Chemo- and Radio-Therapy Based on Modulation of Cell Cycle and Apoptotic Pathways

Index

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