In Aspergillus in the Genomic Era, some aspects of the biology of this genus are covered, including:
- the biotechnological importance of Aspergilli
- their role in mycotoxin contamination of food products including grapes and coffee products
- implications of biodiversity of Aspergillus populations for agriculture
Several chapters deal with the genomic aspects of Aspergilli, including the genomics of pigment biosynthesis, extracellular enzyme production, aflatoxin biosynthesis and the identification of genes taking part in sexual processes.
Additional chapters cover the variability and inheritance of mycoviruses in Aspergilli and multilocus approaches are given to clarify the evolutionary history of the genus.
Finally, a new taxonomic classification of the various Aspergillus sections is given based on multilocus sequence data.
Contents
Phylogenetics and taxonomy of Aspergilli
A review of molecular phylogenetics in Aspergillus, and prospects for a robust genus-wide phylogeny
- Early molecular phylogenetics
- Multilocus approaches
- Successes and shortcomings
- Genomics, and a ‘many locus’ approach
Phylogeny and subgeneric taxonomy of Aspergillus
- Taxonomic outline of the genus Aspergillus based on phylogenetic
analysis of multilocus sequence data
- Subgenus Nidulantes
- Subgenus Circumdati
- Subgenus Fumigati
- Subgenus Terrei
- Subgenus Aspergillus
- Subgenus Candidi
- Species excluded from the Aspergillus genus
- Subgeneric arrangements
Ochratoxin A in profiling and speciation
- Ochratoxin A producing fungi
- Methods for detecting OTA producing fungi
- Ochratoxin A in profiling and speciation
- Some problems in determining OTA production
Aspergillus genomics and genetics
Aspergillus genomics and DHN-melanin conidial pigmentation
- Biochemistry and genetics of DHN-melanin production
- Conidial DHN-melanin pigments and genomics
- Conclusions and future directions
A genomic look at physiology and extracellular enzymes of Aspergillus in
relation to utilization of plant matter
- Plant polysaccharides
- Plant polysaccharide degradation by Aspergillus
- Presence of plant polysaccharide degrading functions in Aspergillus
genomes
- Fungal carbon catabolic pathways related to plant matter
- Regulatory aspects of carbon source utilisation in Aspergillus
- Suitability of genes encoding plant polysaccharide degrading enzymes
for phylogeny
Sexual genes in the asexual filamentous fungus Aspergillus niger and related
Aspergilli
Mycoviruses in the Aspergilli
- An introduction to mycoviruses
- Mycoviruses identified in different Aspergillus species
- Mycovirus dynamics in the black Aspergilli
- Mycovirus dynamics in the Aspergillus nidulans
- Conclusions, perspectives and future research
Aspergilli in the biotechnology and agriculture
Aspergillus in grapes: ecology, biodiversity and genomics
- Aspergillus black rot of grapes
- Ecology, toxigenicity and biodiversity of black Aspergilli
- Structure and biosynthesis of ochratoxins
- Biosynthetic genes in OTA producing fungi
- Molecular tools for identification of black Aspergilli
- Managing the ochratoxin A risk in the grape-food chain
Aspergilli and ochratoxin A in coffee
- Coffee varieties and processing
- Ochratoxin A contamination in coffee
- Ochratoxin A producing fungi in coffee
- Factors affecting ochratoxin production by Aspergillus spp. in coffee
beans
- Reduction of ochratoxin A in coffee processing
- Risk of OTA from coffee consumption
Genetic diversity in Aspergillus flavus and its implications for agriculture
- Biosynthesis
- Sclerotial morphotypes
- Vegetative compatibility and diversity
- Recombination as a source of diversity
- Evolution of the aflatoxin cluster
- Agriculture and A. flavus diversity
The importance of Aspergilli and regulatory aspects of Aspergillus
nomenclature in biotechnology
- History of Aspergillus in biotechnology
- Regulatory approval and nomenclature
- Commercially produced enzymes and pharmaceutical proteins
Clinical apects of Aspergilli
DNA sequence based methods for species identification in the genus
Aspergillus
- Comparative DNA sequencing strategy
- The genus Aspergillus
- Molecular identification of the infrageneric species
- Identification of species within the sections in the genus Aspergillus
Azole resistance in Aspergillus fumigatus
- Antifungal agents
- Intrinsic or primary resistance
- Evolution of resistance to antifungal drugs
- Azole resistance in Aspergillus fumigatus
- Clinical implications of azole resistance
Aspergillus species in human keratomycosis
- Epidemiology of Aspergillus keratitis
- Clinical features of Aspergillus keratitis
- Morphological and molecular diagnosis of Aspergilli from human
keratomycosis
- Animal models for studying Aspergillus keratitis
- Antimycotics for the treatment of Aspergillus keratitis: antifungal
susceptibilities and effectiveness for the therapy of experimental and
clinical infections
- Surgical interventions
- Pathogenesis of Aspergillus keratitis
Index
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