Pharmaceutical Book from C.H.I.P.S.

Autophagy in Immunity and Infection
edited by Vojo Deretic

Autophagy in Immunity and Infection offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms.


  • Features cellular mechanisms and medical implications, structured according to all major pathogens
  • Covers emerging infectious diseases, such as tuberculosis


Overview of Autophagy

  • The Discovery of Autophagy
  • Mechanistic Aspects of Autophagy
  • Autophagy and Immunity

Cell Biology and Biochemistry of Autophagy

  • Autophagic Pathway
  • Regulation of Mammalian Autophagy by Amino Acids and Hormones
  • Methods to Measure Autophagy

Transgenic Models of Autophagy

  • Molecular Mechanism of Mammalian Autophagy
  • Autophagy Indicator Mice: Green Fluorescent Protein (GFP)–LC3 Transgenic Mice
  • Mouse Models Deficient for Autophagy-related Genes

Autophagy in Disease and Aging

  • Autophagy in Neurodegenerative Disorders
  • Autophagy and Cancer
  • Myopathies
  • Liver Diseases
  • Diabetes Mellitus
  • Aging

The Dual Roles for Autophagy in Cell Death and Survival

  • Types of Programmed Cell Death
  • The Contribution of Autophagy to Programmed Cell Death
  • The Combined Activation of Autophagy and Apoptosis during Programmed Cell Death
  • Emerging Relationships between Apoptosis and Autophagy
  • Autophagy and Cell Survival
  • Autophagy and Organism Survival

Autophagy and Mycobacterium tuberculosis

  • M. tuberculosis Blocks Phagolysosome Biogenesis in Macrophages
  • Autophagy and the Host Response to M. tuberculosis
  • Regulation of Autophagy by the Immune System
  • p47 GTPases and Autophagy

Autophagy Eliminates Group A Streptococcus Invading Host Cells

  • Group A Streptococcus (GAS; Streptococcus pyogenes)
  • Adherence to Host Cells by GAS
  • Invasion of Host Cells by GAS
  • Survival of Intracellular Bacteria
  • Streptolysin O (SLO) Enables GAS to Escape form Phagocytic/Endocytic Degradation
  • Autophagy
  • Intracellular GAS is Trapped by Autophagosome-like Compartments
  • Atg5 is Required for Capture and Killing of GAS
  • GcAVs Fuse with Lysosomes for Degradation

Shigella Invasion of Host Cells and Escape from Autophagy

  • Shigella Invasion of Epithelia
  • Shigella Disseminate among Epithelial Cells
  • Shigella Infection Elicits an Inflammatory Response
  • Shigella that do not Produce IcsB Undergo Autophagic Degradation
  • Shigella VirG is a Target for Autophagy, but is Camouflaged by its IcsB

Listeria monocytogenes: A Model System for Studying Autophagy

  • Listeriosis
  • Invasion of Mammalian Cells by L. monocytogenes
  • Autophagy
  • The Ideal Target for Studying the Early Stages of Autophagy
  • Why Other Organisms may not be as Useful to Study the Autophagic Process
  • Assembly of AVs may Result from Fusion of Cytoplasmic Membrane Structures
  • Pathogenic Cytoplasmic Bacteria can avoid the Autophagic Pathway
  • Cellular Fate of Metabolically Inhibited L. monocytogenes

Coxiella burnetii Hijacks the Autophagy Pathway to Survive

  • Coxiella burnetii
  • Bacterium Morphology and Phylogeny
  • Lipopolysaccharide (LPS) and Phases
  • Genome and Genetics
  • Host Response and Immunity
  • Developmental Cycle of C. burnetii: Small Cell Variant (SCV) and Large Cell Variant (LCV)
  • C. burnetii Type IV Secretion System
  • Interaction with the Endocytic and Autophagic Pathways
  • Contribution of Autophagy to RV Development
  • Autophagy and Bacterial Differentiation from SCVs to LCVs
  • Unanswered Questions and Future Perspectives

Utilization of Endoplasmic Reticulum Membranes to Establish a Vacuole that Supports Replication of Legionella pneumophila

  • Evidence that Legionella Utilizes the Autophagy Machinery for Biogenesis of a Replicative Organelle
  • Evidence that the Host Autophagy Machinery is not Essential for Transport or Growth of Legionella
  • Creation of an ER-derived Vacuole that Supports Legionella Replication by Subversion of the Host Secretory Pathway

Endogenous Major Histocompatibility Complex Class II Antigen Processing of Viral Antigens

  • Classical Pathways of Antigen Processing for MHC Presentation
  • Endogenous MHC Class II Antigen Processing of Viral Antigens
  • Autophagic Delivery of Antigens for Lysosomal Degradation and MHC Class II Presentation
  • Similarities Between Sources of MHC Class II Ligands and Autophagy Substrates
  • Overlap Between the Vesicular Transport Pathways of Autophagosomes and MHC Class II Loading Compartments
  • Possible Functions of MHC Class II Presentation after Autophagy in the Immune Control of Viral Infections

Autophagy in Antiviral Host Defense

  • Role of Antiviral Signaling Pathways in Autophagy Regulation
  • Role of Mammalian Autophagy Genes in Antiviral Host Defense
  • Role of Plant Autophagy Genes in Antiviral Host Defense
  • Evasion of Autophagy by Viruses
  • How Might Viral Evasion of Autophagy Contribute to Viral Pathogenesis
  • Autophagy and Antigen Presentation


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Autophagy in Immunity and Infection
edited by Vojo Deretic
2006 • 286 pages • $198.00 + shipping
Texas residents please add 6.75 % sales tax

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