by D. N. Angelov
Axonal Branching and Recovery of Coordinated Muscle Activity after Transection of the Facial Nerve in Adult Rats evaluates the efficiency of various treatments in rats by determining the degree of post-operative exonal branching applying different fluorescent dyes to the zygomatic, buccal, and marginal mandibular branches of the facial nerve, the accuracy ot reinnervation as estimated by the number of double-labeled perikarya innervating the whisker-pad muscles before and after surgery, and the recovery of vibrissal motor performance, estimated by a video based motion analysis.
Contents
Outline of the General Neurobiological Problem
- The Perikarya Supporting Axonal Regrowth Are Hyperexcitable
- Axonal Regrowth Is Compromised by Ephaptic Cross-Talk Between the Branches
- Biological Significance of Axonal Branching
- Role of the Cytoskeleton Reorganization During Axonal Regrowth
- The Individual Guidance Cues Promoting Reinnervation of Original Targets Are Still Unknown
Materials and Methods: Experimental Sets
- First Set of Experiments: Attempts to Reduce Collateral Axonal Branching by Alterations of the Trigeminal Input to the Facial Perikarya
- Second Set of Experiments: Attempts to Reduce Collateral Axonal Branching at the Lesion Site
Results
- Influence of the Altered Input to Axotomized Facial Perikarya on the Quality of Reinnervation
- Attempts to Reduce Collateral Axonal Branching at the Lesion Site
Discussion
- The Combined Approach to Evaluate the Quality of Peripheral Nerve Regeneration
- Sensory-Motor Integrity as a Factor in Motor Regeneration
- Manipulations of the Conditions at the Lesion Site Cause Changes in the Quality of Axonal Regeneration and Recovery of Function
- Collateral Branching Versus Terminal Sprouting of Axons
Summary
Index
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