Presenting data from human studies and trials, along with recent research findings, Bioactive Peptides: Applications for Improving Nutrition and Health summarizes the applications and benefits of bioactive peptides used to mitigate major metabolic derangements that arise from chronic illnesses and result in unwanted weight loss.

Features:

• Summarizes state-of-the-art research on bioactive proteins and peptides
• Presents data from recent human clinical trials
• Considers the benefits of bioactive proteins in supporting healthy weight when managing illness that commonly cause pathologic weight loss
• Supports findings with more than 2000 references and over 100 tables and figures

Contents

Nutrition and the Host Response to Infection and Injury

• Nutrition and Illness
• Host Response to Injury
• Unintended Weight Loss
• Multimodal Nutritional Support Using Bioactive Peptides

Bioactive Peptides for Nutrition and Health

• Legislation
• Bioactive Peptides and Proteins
• Applications of Protein Supplements for Health
• Perspectives on Human Trial Data

Dietary Protein Requirements for Health

• Dietary Protein Quality Relation to Health
• Protein Requirements and Health
• Dietary Protein and Host Responses to Illness
• Peptides and Protein Bioactivity
• Types of Dietary Protein Health Effects

Protein Turnover and Economics within the Body

• Protein Turnover and Wasting
• Baseline Whole Body Protein Turnover
• Regional Protein Turnover
• Nutrients and Protein Turnover
• Slow and Fast Proteins

Major Processes for Muscle Gain and Loss

• Myostatin
• Muscle Cell Death and Atrophy
• Proteolysis via Ubiquitin Proteasome
• Further Signaling Pathways for Muscle Atrophy
• Mammalian Target of Rapamycin and Hypertrophy

Inflammation and Innate Immune Response

• Types of Inflammation
• Proinflammatory Signaling
• Anti-Inflammatory Bioactive Peptides and Supplements
• In Vivo Applications and Controlled Trials

Infection and Sepsis

• Pathogen Recognition and Intracellular Signaling
• Host Antimicrobial Peptides
• Functions of Antimicrobial Peptides
• In Vivo Applications and Human-Trials of AMPs

Anabolic Dysfunction

• Insulin and Muscle Protein Metabolism
• Growth Hormone and IGF-1
• Growth Hormone Secretagogues
• Leucine, BCAA, and Related Peptides
• In Vivo Applications and Clinical Trials

Bioactive Peptides for Alleviating Illness Anorexia

• Illness Anorexia
• Leptin and Food Intake
• Melanocortin Peptides
• Ghrelin
• Other Bioactive Peptides for Moderating Appetite
• In Vivo Studies and Controlled Trials

Index

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