Biocatalysis in the Pharmaceutical and Biotechnology Industries considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout.

Features:

• Demonstrates how biocatalysts are used in stereoinversion, enantioconvergence, deracemization processes, and other chemical modifications
• Describes the chemoenzymatic synthesis of anticancer agents, antihypertensive drugs, antiviral agents, immunosuppressive compounds, analgesic drugs, antidepressants, anticancer drugs, anticholesterol drugs, serotonin uptake inhibitors, and more
• Highlights the use of organic, renewable, and microbial starting materials
• Presents strategies and opportunities for using chiral switches in the preparation of various pharmaceuticals
• Contains over 4000 references and more than 1000 tables, equations, drawings, and color micrographs

Contents

1. Nitrilases and Nitrile Hydratases
2. Biocatalytic Deracemization: Dynamic Resolution, Stereoinversion, Enantioconvergent Processes and Cyclic Deracemization
3. A Decade of Biocatalysis at Glaxo Wellcome
4. Biocatalysis for Synthesis of Chiral Pharmaceutical Intermediates
5. Directed Evolution of Lipases and Esterases for Organic Synthesis
6. Flavin-Containing Oxidative Biocatalysts
7. Preparation of Chiral Pharmaceuticals Through Enzymatic Acylation of Alcohols Amines
8. Dynamic Kinetic Resolution and Asymmetric Transformations by Enzyme-Metal Combination
9. Biotransformation of Natural or Synthetic Compounds for the Generation of Molecular Diversity
10. Applications of Aromatic Hydrocarbon Dioxygenases
11. A Genomic Approach to Investigating Baker's Yeast Reductions
12. Immobilization of Enzymes as Cross-linked Enzyme Aggregates: A Simple Method for Improving Performance
13. Biotechnological Applications of Aldolases
14. Enzymatic Synthesis of Modified Nucleosides
15. Biocatalytic Reduction of Carboxylic Acids: Mechanism and Applications
16. Enzymatic Synthesis of Sugar Esters and Oligosaccharides from Renewable Resources
17. Efficient Methods and Instrumentation for Engineering Custom Enzymes
18. Deaminating Enzymes of the Purine Cycle as Biocatalysts for Chemoenzymatic Synthesis and Transformation of Antiviral Agents Structurally Related to Purine Nucleosides
19. Microbial and Enzymatic Processes for the Production of Chiral Compounds
20. Discovery of Arylmalonate Decarboxylase and Conversion of the Function by Rational Design
21. Chemoenzymatic Preparation of Enantiopure Building Blocks of Synthetic Utility
22. Stereoselective Modifications of Polyhydroxylated Steroids
23. Recent Developments in Enzymatic Acyloin Condensations
24. Synthesis of Chiral Alcohols with Carbonyl Reductase Library and Robust NAD(P)H Regenerating System
25. Comparative Analysis of Chemical and Biocatalytic Syntheses of Drug Intermediates
26. Industrial Processes Using Lyases for C-C, C-N, and C-O Bond Formation
27. State of the Art and Applications in Stereoselective Synthesis of Chiral Cyanohydrins
28. Chiral Switches: Problems, Strategies, Opportunities and Experiences
29. Enzyme Evolution for Chemical Process Applications
30. Biocatalytic Routes to Nonracemic Chiral Amines
31. Enantioselective Biocatalytic Reduction of Ketones for the Synthesis of Optically Active Alcohols
32. Enzyme Catalysis in Non-Aqueous Media: Past-Present-Future

Index

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