Research book from C.H.I.P.S.

Biology of Depression
From Novel Insights to Therapeutic Strategies
2-Volume Set
edited by Julio Licinio

Biology of Depression is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression.

Biology of Depression presents the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches.

In addition, Biology of Depression covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.


  1. Classification of Depression: Research and Diagnostic Criteria: DSM-IV and ICD-10
  2. Psychosocial and Environmental Formulations of Depression
  3. The Economic Burden of Depression: Societal and Patient Perspectives
  4. The Depressive Spectrum: Reconceptualizing the Relationship between Dysthymic, Subthreshold and Major Depressions
  5. The Monoamine Hypothesis of Depression
  6. Monoaminergic-based Pharmacotherapy for Depression
  7. Psychobiology of Electroshock
  8. Current Prognosis of Depression
  9. Treatment of Depression in Medical Illness
  10. Depression and Suicidality in Children and Adolescents
  11. The Biology and Genetics of Suicidality
  12. Geriatric Depression
  13. Comorbidity of Depression and Substance Abuse
  14. Depression in the Context of Cancer
  15. Treatment of Refractory Depression
  16. Clinical Pharmacology of New Classes of Antidepressant Drugs
  17. Neuroimaging and Neuropathological Studies of Mood Disorders
  18. Dysregulation of Circadian Rhythms in Mood Disorders: Molecular Mechanisms
  19. Neuropeptidergic Dysfunction in Depression
  20. Depression, Mania, and Thyroid Function: A Story of Intimate Relationships
  21. Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities
  22. Neuroimmune Mediators: Are Cytokines Mediators of Depression?
  23. Borna Disease Virus: Impact on Mood and Cognition
  24. Depression and Heart Disease
  25. Genetic Substrates Shared by Depression and Cardiovascular Disease
  26. History and Epidemiology of Depression
  27. Major Depression and Animals Models
  28. Loss and Deprivation: From Animal Models to Clinical Presentation
  29. Neurogenomics of depression
  30. Genetic Approaches to Depression: Linkage Studies
  31. Genetic Approaches to Depression: Association Studies
  32. Molecular Effects of Antidepressant Treatments
  33. The Role of Transcription Factors in the Biology of Depression
  34. Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action
  35. Pharmacogenetics of Antidepressant Drug Metabolism and Its Clinical Implications
  36. Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response
  37. Emerging Treatments for Depression: Beyond the Monoamine Hypothesis
  38. Antidepressants and Suicide: Clinical Considerations
  39. Depression in Developing Countries
  40. Complementary and Alternative Medical Treatment for Depression
  41. The Experience of Depression


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Biology of Depression
From Novel Insights to Therapeutic Strategies
2-Volume Set
edited by Julio Licinio

2005 1055 pages $604.00 + shipping
Texas residents please add 6.75 % sales tax

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