Biology of Depression is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression.

Biology of Depression presents the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches.

In addition, Biology of Depression covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.

Contents

1. Classification of Depression: Research and Diagnostic Criteria: DSM-IV and ICD-10
2. Psychosocial and Environmental Formulations of Depression
3. The Economic Burden of Depression: Societal and Patient Perspectives
4. The Depressive Spectrum: Reconceptualizing the Relationship between Dysthymic, Subthreshold and Major Depressions
5. The Monoamine Hypothesis of Depression
6. Monoaminergic-based Pharmacotherapy for Depression
7. Psychobiology of Electroshock
8. Current Prognosis of Depression
9. Treatment of Depression in Medical Illness
10. Depression and Suicidality in Children and Adolescents
11. The Biology and Genetics of Suicidality
12. Geriatric Depression
13. Comorbidity of Depression and Substance Abuse
14. Depression in the Context of Cancer
15. Treatment of Refractory Depression
16. Clinical Pharmacology of New Classes of Antidepressant Drugs
17. Neuroimaging and Neuropathological Studies of Mood Disorders
18. Dysregulation of Circadian Rhythms in Mood Disorders: Molecular Mechanisms
19. Neuropeptidergic Dysfunction in Depression
20. Depression, Mania, and Thyroid Function: A Story of Intimate Relationships
21. Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities
22. Neuroimmune Mediators: Are Cytokines Mediators of Depression?
23. Borna Disease Virus: Impact on Mood and Cognition
24. Depression and Heart Disease
25. Genetic Substrates Shared by Depression and Cardiovascular Disease
26. History and Epidemiology of Depression
27. Major Depression and Animals Models
28. Loss and Deprivation: From Animal Models to Clinical Presentation
29. Neurogenomics of depression
30. Genetic Approaches to Depression: Linkage Studies
31. Genetic Approaches to Depression: Association Studies
32. Molecular Effects of Antidepressant Treatments
33. The Role of Transcription Factors in the Biology of Depression
34. Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action
35. Pharmacogenetics of Antidepressant Drug Metabolism and Its Clinical Implications
36. Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response
37. Emerging Treatments for Depression: Beyond the Monoamine Hypothesis
38. Antidepressants and Suicide: Clinical Considerations
39. Depression in Developing Countries
40. Complementary and Alternative Medical Treatment for Depression
41. The Experience of Depression

Index

click here to see books • videos • cd-roms of related interest

ORDER NOW Biology of Depression From Novel Insights to Therapeutic Strategies 2-Volume Set edited by Julio Licinio 2005 • 1055 pages • $604.00 + shipping Texas residents please add 6.75 % sales tax