Biomarkers in Medicine, Drug Discovery, and Environmental Health provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers.

The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

Contents

1. Biomarkers: An Evolutionary Perspective

Section I: Tools for Biomarker Discovery

2. Genomics
3. Proteomics for Biomarker Discovery
4. Metabolic Profiling for Biomarker Discovery
5. The Bittersweet Promise of Glycobiology

Section II: Biomarkers of Injury/Disease

6. Biomarkers of Alzheimer's and Parkinson's Disease
7. Biomarkers of Cardiac Injury
8. Lung Injury Biomarkers
9. Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities
10. Biomarkers of Acute Kidney Injury
11. In Search of Biomarkers for Drug-Induced Vascular Injury
12. Biomarkers of Immunotoxicity
13. Biomarkers in Obstetric Medicine
14. Biomarkers in Cancer
15. Biomarkers of HIV
16. Biomarkers of In Vitro Drug-Induced Mitochondrial Dysfunction

Section III: Technology for Biomarker Detection

17. Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research
18. Nanoscale Techniques for Biomarker Quantification
19. Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices

Section IV: Hot Topics in Biomarker Research

20. Biomarkers for Environmental Exposure
21. Clinical Study Design in Biomarker Research
22. Statistical Issues in Biomarker Research
23. Regulatory Perspective for Biomarker Qualification from U.S. FDA
24. The European Medicines Agency Approach

Index

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