This reference provides an in-depth investigation of advances in biodegradable hydrogels.
Based on extensive research and experience, the book is the first to deal exclusively with this important area in drug delivery.
A valuable guide for both student and experienced professional, it begins with a detailed introduction to current biodegradable hydrogel technology. Following chapters present advanced R&D, delivery systems, and more.
Contents
- Introduction
Controlled Release Drug Delivery Systems
Hydrogels
- Biodegradation
Definitions of Biodegradation
Mechanisms of Biodegradation
Chemical Hydrolysis of Polymers
Biodegradable Hydrogels
- Types of Biodegradable Hydrogels
Hydrogels with Degradable Polymer Backbone
Hydrogels with Degradable Crosslinking Agents
Hydrogels with Degradable Pendant Chains
- Chemical Gels
Polymerization in the Presence of Crosslinking Agents
Crosslinking of Water-Soluble Polymers
- Physical Gels
Thermoreversible Gelling System
Thermoreversible Gelling Polysaccharides
Physical Gelation by Ion Complexation
Physical Gelation by Specific Interactions
Determination of the Crosslink Density
- Chemically-Induced Degradation
Chemically-Induced Hydrolysis in the Body
Chemically-Induced Hydrolysis of Polyesters
Polyester Hydrogels
- Enzyme-Catalyzed Degradation
Properties of Enzymes
Hydrolytic Enzymes in the Body
Factors Influencing Enzyme-Catalyzed Reactions
Enzyme-Catalyzed Degradation of Modified Proteins
Enzyme-Catalyzed Degradation of Modified Polysaccharides
- Biodegradable Drug Delivery Systems
Mechanisms of Drug Release
Drug Release from Hydrogels with Biodegradable Backbones
Drug Release from Hydrogels with Degradable Crosslinking Agents
Drug Release from Hydrogels with Biodegradable Pendant Chains
- Future Development
Drug Loading
Drug Targeting
Drug Release
Degradation and Elimination
The Use of Bioactive Polymers
Index
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